LongevityMap Gene

Gene details

HGNC symbol
POLDIP3 
Aliases
SKAR; PDIP46 
Common name
DNA polymerase delta interacting protein 3 
Description
This gene encodes an RRM (RNA recognition motif)-containing protein that participates in the regulation of translation by recruiting ribosomal protein S6 kinase beta-1 to mRNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Cytogenetic Location
22q13.2
UCSC Genome Browser
View 22q13.2 on the UCSC genome browser
OMIM
611520
Ensembl
ENSG00000100227
UniProt/Swiss-Prot
B4E0L0_HUMAN
Entrez Gene
84271
UniGene
505802
1000 Genomes
1000 Genomes

Homologs in model organisms

Danio rerio
LOC100536140
Mus musculus
Poldip3
Rattus norvegicus
Poldip3

Studies (1)

Significant/Non-significant: 1/0

Longevity Association
Significant
Population
Dutch
Study Design
1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls
Conclusions
As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing
Indentifier
POLDIP3
Reference