LongevityMap Gene

Gene details

HGNC symbol
POLB 
Aliases
 
Common name
DNA polymerase beta 
Description
The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011]
Cytogenetic Location
8p11.21
UCSC Genome Browser
View 8p11.21 on the UCSC genome browser
OMIM
174760
Ensembl
ENSG00000070501
UniProt/Swiss-Prot
B7Z1W5_HUMAN
Entrez Gene
5423
UniGene
654484
1000 Genomes
1000 Genomes

Homologs in model organisms

Danio rerio
polb
Mus musculus
Polb
Rattus norvegicus
Polb
Saccharomyces cerevisiae
POL4

In other databases

GenAge human genes
  • This gene is present as POLB

Studies (2)

Significant/Non-significant: 1/1

Study 1

Longevity Association
Significant
Population
Danish
Study Design
Alleles in candidate pathways (GH/IGF1 signaling, DNA damage signaling and repair and pro/antioxidants) were investigated for association with longevity in 1089 oldest-old (age 92-93) and 736 middle-aged Danes
Conclusions
Eleven SNPs (in GSR, KL, GHRHR, INS, GHSR, IGF2R, RAD52, WRN, RAD23B, POLB and NTLH1) were associated with longevity after correction for multiple hypothesis testing. No replications were observed in German and Dutch populations.
Indentifier
rs2953983
Reference

    Study 2

    Longevity Association
    Non-significant
    Population
    Danish
    Study Design
    592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
    Conclusions
    The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
    Indentifier
    rs3136717
    Reference