LongevityMap Gene

Gene details

HGNC symbol
PLCB3 
Aliases
 
Common name
phospholipase C beta 3 
Description
This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Cytogenetic Location
11q13.1
UCSC Genome Browser
View 11q13.1 on the UCSC genome browser
OMIM
600230
Ensembl
ENSG00000149782
UniProt/Swiss-Prot
PLCB3_HUMAN
Entrez Gene
5331
UniGene
523761
1000 Genomes
1000 Genomes

Homologs in model organisms

Danio rerio
plcb3
Mus musculus
Plcb3
Rattus norvegicus
Plcb3

Studies (1)

Significant/Non-significant: 0/1

Longevity Association
Non-significant
Population
German
Study Design
Genome-wide association study comparing 664,472 autosomal SNPs in 763 long-lived individuals (mean age: 99.7 years) and 1085 controls (mean age: 60.2 years). Top SNPs from the GWAS were further investigated in an independent German sample comprised of 754 long-lived individuals (mean age: 96.9 years) and 860 controls (mean age: 67.3 years).
Conclusions
Thirty-two SNPs previously associated with longevity were not associated with longevity in this study
Indentifier
rs2244621
Reference