LongevityMap Gene

Gene details

HGNC symbol
PARVG 
Aliases
 
Common name
parvin gamma 
Description
Members of the parvin family, including PARVG, are actin-binding proteins associated with focal contacts.[supplied by OMIM, Aug 2004]
Cytogenetic Location
22q13.31
UCSC Genome Browser
View 22q13.31 on the UCSC genome browser
OMIM
608122
Ensembl
ENSG00000138964
UniProt/Swiss-Prot
A0A024R4U4_HUMAN
Entrez Gene
64098
UniGene
658995
1000 Genomes
1000 Genomes

Homologs in model organisms

Danio rerio
parvg
Mus musculus
Parvg
Rattus norvegicus
Parvg

Studies (1)

Significant/Non-significant: 1/0

Longevity Association
Significant
Population
American (Caucasian)
Study Design
Genome-wide association study using 1,471 genotyped participants from the Framingham Heart Study, of which 1,173 individuals had known lifespans, plus 517 individuals from the Offspring cohort for validating connections between longevity and genetic variants
Conclusions
A total of 27 SNPs, including in CDH4, SVEP1, CACNA1C, CARS, STK24, C7orf50, PARVG, NCAM2, PPP2R2C, NLRC5, BTBD9, RAC2, TGFA, KIAA0649, ABCC4, CLSTN2, FAM19A5 and RUNX3, were identified at the intersection of various statistical procedures
Indentifier
rs139170
Reference