LongevityMap Gene

Gene details

HGNC symbol
NNMT 
Aliases
 
Common name
nicotinamide N-methyltransferase 
Description
N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
OMIM
600008
Ensembl
ENSG00000166741
UniProt/Swiss-Prot
NNMT_HUMAN
Entrez Gene
4837
UniGene
503911
1000 Genomes
1000 Genomes

Homologs in model organisms

Caenorhabditis elegans
anmt-3
Mus musculus
Nnmt
Rattus norvegicus
Nnmt

Studies (1)

Significant/Non-significant: 0/1

Longevity Association
Non-significant
Population
Italian (Southern)
Study Design
A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
Conclusions
After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
Indentifier
rs1941404
Reference