LongevityMap Gene
Gene details
- HGNC symbol
- NEO1
- Aliases
- NGN; IGDCC2; NTN1R2
- Common name
- neogenin 1
- Description
- This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
- Cytogenetic Location
- 15q24.1
- UCSC Genome Browser
- View 15q24.1 on the UCSC genome browser
- OMIM
- 601907
- Ensembl
- ENSG00000067141
- UniProt/Swiss-Prot
- NEO1_HUMAN
- Entrez Gene
- 4756
- UniGene
- 388613
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- unc-40
- Danio rerio
- neo1a
- Danio rerio
- neo1b
- Drosophila melanogaster
- fra
- Mus musculus
- Neo1
- Rattus norvegicus
- Neo1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Caucasians
- Study Design
- Meta-analysis of GWAS in Caucasians from four prospective cohort studies: the Age, Gene/Environment Susceptibility-Reykjavik Study, the Cardiovascular Health Study, the Framingham Heart Study, and the Rotterdam Study participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Longevity was defined as survival to age 90 years or older (n = 1,836); the comparison group comprised cohort members who died between the ages of 55 and 80 years (n = 1,955).
- Conclusions
- There were 273 single-nucleotide polymorphism (SNP) associations with p < .0001, but none reached significance after correcting for multiple testing
- Indentifier
- rs7170328
- Reference