LongevityMap Gene

Gene details

HGNC symbol
NADSYN1 
Aliases
 
Common name
NAD synthetase 1 
Description
Nicotinamide adenine dinucleotide (NAD) is a coenzyme in metabolic redox reactions, a precursor for several cell signaling molecules, and a substrate for protein posttranslational modifications. NAD synthetase (EC 6.3.5.1) catalyzes the final step in the biosynthesis of NAD from nicotinic acid adenine dinucleotide (NaAD).[supplied by OMIM, Apr 2004]
Cytogenetic Location
11q13.4
UCSC Genome Browser
View 11q13.4 on the UCSC genome browser
OMIM
608285
Ensembl
ENSG00000172890
UniProt/Swiss-Prot
NADE_HUMAN
Entrez Gene
55191
UniGene
556986
1000 Genomes
1000 Genomes

Homologs in model organisms

Caenorhabditis elegans
qns-1
Danio rerio
nadsyn1
Drosophila melanogaster
CG9940
Mus musculus
Nadsyn1
Rattus norvegicus
Nadsyn1
Saccharomyces cerevisiae
QNS1
Schizosaccharomyces pombe
SPCC553.02

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as CG9940

Studies (1)

Significant/Non-significant: 0/1

Longevity Association
Non-significant
Population
Dutch
Study Design
Single nucleotide polymorphisms (SNPs) associated with vitamin D levels were studied in the offspring (n = 1038) of nonagenarians who had at least one nonagenarian sibling. The offsprings' partners (n = 461) were used as controls.
Conclusions
No SNP was found to be associated with longevity after correcting for multiple testing, though the offspring had a slightly lower frequency of a genetic variant (rs2060793) in CYP2R1
Indentifier
rs3829251
Reference