LongevityMap Gene

Gene details

HGNC symbol
MAP3K7 
Aliases
CSCF; FMD2; TAK1; MEKK7; TGF1a 
Common name
mitogen-activated protein kinase kinase kinase 7 
Description
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Cytogenetic Location
6q15
UCSC Genome Browser
View 6q15 on the UCSC genome browser
OMIM
602614
Ensembl
ENSG00000135341
UniProt/Swiss-Prot
M3K7_HUMAN
Entrez Gene
6885
UniGene
594838
1000 Genomes
1000 Genomes

Homologs in model organisms

Caenorhabditis elegans
CELE_Y105C5A.24
Danio rerio
map3k7
Drosophila melanogaster
Tak1
Mus musculus
Map3k7
Rattus norvegicus
Map3k7

In other databases

CellAge
  • This gene is present as MAP3K7

Studies (2)

Significant/Non-significant: 1/1

Study 1

Longevity Association
Significant
Population
Italian (Southern)
Study Design
A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
Conclusions
After adjustment for multiple testing, rs282070 was significantly associated with longevity (P  = 1.1 × 10−3). The C allele carriers showed an increased chance to attain longevity
Indentifier
rs282070
Reference

    Study 2

    Longevity Association
    Non-significant
    Population
    Italian (Southern)
    Study Design
    A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
    Conclusions
    After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
    Indentifier
    rs157703
    Reference