LongevityMap Gene

Gene details

HGNC symbol
LYPD6 
Aliases
 
Common name
LY6/PLAUR domain containing 6 
Description
Members of the LY6 protein family (see SLURP1; MIM 606119), such as LYPD6, have at least one 80-amino acid LU domain that contains 10 conserved cysteines with a defined disulfide-bonding pattern (Zhang et al., 2010 [PubMed 19653121]).[supplied by OMIM, Apr 2010]
Cytogenetic Location
2q23.2
UCSC Genome Browser
View 2q23.2 on the UCSC genome browser
OMIM
613359
Ensembl
ENSG00000187123
UniProt/Swiss-Prot
LYPD6_HUMAN
Entrez Gene
130574
UniGene
21929
1000 Genomes
1000 Genomes

Homologs in model organisms

Danio rerio
lypd6
Mus musculus
Lypd6
Rattus norvegicus
Lypd6

Studies (1)

Significant/Non-significant: 0/1

Longevity Association
Non-significant
Population
Caucasians
Study Design
Meta-analysis of GWAS in Caucasians from four prospective cohort studies: the Age, Gene/Environment Susceptibility-Reykjavik Study, the Cardiovascular Health Study, the Framingham Heart Study, and the Rotterdam Study participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Longevity was defined as survival to age 90 years or older (n = 1,836); the comparison group comprised cohort members who died between the ages of 55 and 80 years (n = 1,955).
Conclusions
There were 273 single-nucleotide polymorphism (SNP) associations with p < .0001, but none reached significance after correcting for multiple testing
Indentifier
rs1420356
Reference