LongevityMap Gene

Gene details

HGNC symbol
LRRC56 
Aliases
 
Common name
leucine rich repeat containing 56 
Description
Cytogenetic Location
11p15.5
UCSC Genome Browser
View 11p15.5 on the UCSC genome browser
OMIM
Ensembl
ENSG00000161328
UniProt/Swiss-Prot
LRC56_HUMAN
Entrez Gene
115399
UniGene
567655
1000 Genomes
1000 Genomes

Homologs in model organisms

Danio rerio
uncharacterized_F1QS
Mus musculus
Lrrc56
Rattus norvegicus
Lrrc56

Studies (1)

Significant/Non-significant: 0/1

Longevity Association
Non-significant
Population
Italian (Southern)
Study Design
A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
Conclusions
After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
Indentifier
rs4963176
Reference