LongevityMap Gene

Gene details

HGNC symbol
LPL 
Aliases
LIPD; HDLCQ11 
Common name
lipoprotein lipase 
Description
LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008]
Cytogenetic Location
8p21.3
UCSC Genome Browser
View 8p21.3 on the UCSC genome browser
OMIM
609708
Ensembl
ENSG00000175445
UniProt/Swiss-Prot
A0A1B1RVA9_HUMAN
Entrez Gene
4023
UniGene
180878
1000 Genomes
1000 Genomes

Homologs in model organisms

Danio rerio
uncharacterized_H9GY
Mus musculus
Lpl
Rattus norvegicus
Lpl

Studies (1)

Significant/Non-significant: 0/1

Longevity Association
Non-significant
Population
Japanese
Study Design
PvuII and HindIII polymorphisms were examined in 256 centenarians and 190 healthy younger controls (22-65 years old)
Conclusions
The allelic frequencies were not different between the two groups
Indentifier
LPL
Reference