LongevityMap Gene

Gene details

HGNC symbol
LOC105378963 
Aliases
 
Common name
uncharacterized LOC105378963 
Description
Cytogenetic Location
5q11.2
UCSC Genome Browser
View 5q11.2 on the UCSC genome browser
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene
105378963
UniGene
1000 Genomes
1000 Genomes

Homologs in model organisms

No homologs found

Studies (1)

Significant/Non-significant: 0/1

Longevity Association
Non-significant
Population
German
Study Design
Genome-wide association study comparing 664,472 autosomal SNPs in 763 long-lived individuals (mean age: 99.7 years) and 1085 controls (mean age: 60.2 years). Top SNPs from the GWAS were further investigated in an independent German sample comprised of 754 long-lived individuals (mean age: 96.9 years) and 860 controls (mean age: 67.3 years).
Conclusions
Fifteen SNPs had indicative association with longevity, even if not statistically significant after correcting for multiple hypothesis testing. None of these SNPs were validated in the follow-up analysis. Since rs12741354 (in ASTN1) was nearly significant, it was further investigated in French centenarians but it failed to be associated with longevity.
Indentifier
rs350450
Reference