LongevityMap Gene

Gene details

HGNC symbol
LIG1 
Aliases
 
Common name
DNA ligase 1 
Description
This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Cytogenetic Location
19q13.33
UCSC Genome Browser
View 19q13.33 on the UCSC genome browser
OMIM
126391
Ensembl
ENSG00000105486
UniProt/Swiss-Prot
B4DM52_HUMAN
Entrez Gene
3978
UniGene
1770
1000 Genomes
1000 Genomes

Homologs in model organisms

Caenorhabditis elegans
lig-1
Danio rerio
si:dkeyp-35b8.5
Drosophila melanogaster
DNA-ligI
Mus musculus
Lig1
Rattus norvegicus
LOC100911727
Saccharomyces cerevisiae
CDC9
Schizosaccharomyces pombe
cdc17

Studies (1)

Significant/Non-significant: 0/1

Longevity Association
Non-significant
Population
Danish
Study Design
592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
Conclusions
The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
Indentifier
rs274860
Reference