LongevityMap Gene

Gene details

HGNC symbol
KIFC3 
Aliases
 
Common name
kinesin family member C3 
Description
This gene encodes a member of the kinesin-14 family of microtubule motors. Members of this family play a role in the formation, maintenance and remodeling of the bipolar mitotic spindle. The protein encoded by this gene has cytoplasmic functions in the interphase cells. It may also be involved in the final stages of cytokinesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Cytogenetic Location
16q21
UCSC Genome Browser
View 16q21 on the UCSC genome browser
OMIM
604535
Ensembl
ENSG00000140859
UniProt/Swiss-Prot
B7Z5U4_HUMAN
Entrez Gene
3801
UniGene
23131
1000 Genomes
1000 Genomes

Homologs in model organisms

Caenorhabditis elegans
klp-17
Danio rerio
kifc3
Mus musculus
Kifc3
Rattus norvegicus
Kifc3

Studies (1)

Significant/Non-significant: 0/1

Longevity Association
Non-significant
Population
Italian
Study Design
Genome-wide association study on 410 long-living individuals (age range, 90–109 years) and 553 young control individuals (age range, 18–48 years) using 318,237 SNPs. An independent population with 116 long-lived individuals and 160 controls was used for replication purposes.
Conclusions
A total of 67 SNPs were identified with an indication of potentially being associated with longevity (p < 1 × 10−4), though 66 were not further validated
Indentifier
rs1582594
Reference