LongevityMap Gene

Gene details

HGNC symbol
ITGB3 
Aliases
GT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16 
Common name
integrin subunit beta 3 
Description
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
Cytogenetic Location
17q21.32
UCSC Genome Browser
View 17q21.32 on the UCSC genome browser
OMIM
173470
Ensembl
ENSG00000259207
UniProt/Swiss-Prot
ITB3_HUMAN
Entrez Gene
3690
UniGene
218040
1000 Genomes
1000 Genomes

Homologs in model organisms

Caenorhabditis elegans
pat-3
Danio rerio
itgb3b
Drosophila melanogaster
mys
Mus musculus
Itgb3
Rattus norvegicus
Itgb3

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as mys
  • A homolog of this gene for Caenorhabditis elegans is present as pat-3

Studies (2)

Significant/Non-significant: 1/1

Study 1

Longevity Association
Non-significant
Population
Danish
Study Design
L/P33 SNP was examined in 187 Danish centenarians and 201 healthy controls aged 20-64 years (mean age 42 years)
Conclusions
No significant association with longevity was found
Indentifier
33L/P
Reference

    Study 2

    Longevity Association
    Significant
    Population
    American (Caucasian)
    Study Design
    T1565C SNP was examined in 2689 healthy Caucasians aged 17-39 years (n = 979; 505 males and 474 females), 40-59 years (n = 900; 526 males and 374 females), and 60-85 years (n = 810; 530 males and 280 females)
    Conclusions
    The Pl(A2) allele frequency significantly decreased with age
    Indentifier
    T1565C
    Reference