LongevityMap Gene

Gene details

HGNC symbol: IL1RN
Aliases: DIRA; IRAP; IL1F3; IL1RA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA
Common name: interleukin 1 receptor antagonist
Description: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jan 2016]
Cytogenetic Location: 2q14.1
UCSC Genome Browser: View 2q14.1 on the UCSC genome browser
OMIM: 147679
Ensembl: ENSG00000136689
UniProt/Swiss-Prot: A0A024R528_HUMAN
Entrez Gene: 3557
UniGene: 81134
1000 Genomes: 1000 Genomes

Homologs in model organisms

Mus musculus: Il1rn
Rattus norvegicus: Il1rn

In other databases

CellAge

This gene is present as IL1RN

Studies (2)

Significant/Non-significant: 0/2

Study 1

Longevity Association

Non-significant

Population

Study Design

250 (52 males and 198 females) nonagenarians and 400 healthy control (18-60 years old) were examined for VNTR polymorphism in intron 2 (an 86 bp repeat sequence)

Conclusions

No significant differences relative to longevity were found

Indentifier

Reference

Study 2

Longevity Association

Non-significant

Population

Italian (Northern and Central)

Study Design

The 86-bp repeated sequence in intron 2 was examined in 1131 unrelated individuals aged 20-102 years (453 females and 678 males, including 94 female and 40 male centenarians)

Conclusions

No significant differences in the genotype and allele frequency distributions were observed between young, elderly and centenarian subjects

Indentifier

Reference