LongevityMap Gene

Gene details

HGNC symbol
IL12RB2 
Aliases
 
Common name
interleukin 12 receptor subunit beta 2 
Description
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]
Cytogenetic Location
1p31.3
UCSC Genome Browser
View 1p31.3 on the UCSC genome browser
OMIM
601642
Ensembl
ENSG00000081985
UniProt/Swiss-Prot
A0A0A0MTN7_HUMAN
Entrez Gene
3595
UniGene
479347
1000 Genomes
1000 Genomes

Homologs in model organisms

Danio rerio
uncharacterized_E9QH
Mus musculus
Il12rb2
Rattus norvegicus
Il12rb2

Studies (1)

Significant/Non-significant: 0/1

Longevity Association
Non-significant
Population
Korean
Study Design
463 biomarkers in 176 disease associated genes were examined in 137 long lived individuals (>90 y, 59.1% female, 96.73 ± 3.97 y) and 213 young controls (12-14 y, 39.4% female, 12.93 ± 0.80)
Conclusions
Associations between several genes and longevity were detected at a P-value less than 0.01, though most were not significant after correcting for multiple hypothesis testing
Indentifier
rs2030071
Reference