LongevityMap Gene

Gene details

HGNC symbol
IL10 
Aliases
CSIF; TGIF; GVHDS; IL-10; IL10A 
Common name
interleukin 10 
Description
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]
Cytogenetic Location
1q32.1
UCSC Genome Browser
View 1q32.1 on the UCSC genome browser
OMIM
124092
Ensembl
ENSG00000136634
UniProt/Swiss-Prot
IL10_HUMAN
Entrez Gene
3586
UniGene
193717
1000 Genomes
1000 Genomes

Homologs in model organisms

Danio rerio
il10
Mus musculus
Il10
Rattus norvegicus
Il10

Studies (9)

Significant/Non-significant: 4/5

Study 1

Longevity Association
Significant
Population
Italian
Study Design
-1082 G/A SNP was examined in 72 centenarian men, 102 centenarian women and healthy unrelated controls (115 men and 112 women, aged 22-60 years)
Conclusions
The number of male centenarians homozygous for the -1082G genotype, suggested to be associated with high IL-10 production, was significantly increased in comparison with younger control subjects. No significant differences were observed between women and controls.
Indentifier
-1082G/A
Reference

    Study 2

    Longevity Association
    Non-significant
    Population
    Irish
    Study Design
    100 control samples (59% female and 41% male) and 93 aged consecutive samples (70% female, 30% male with an age range of 80-97 years) were analyzed for -1082G/A SNP
    Conclusions
    No significant differences were observed in centenarians and controls
    Indentifier
    -1082G/A
    Reference

      Study 3

      Longevity Association
      Non-significant
      Population
      Italian (Sardinia)
      Study Design
      112 (36 male, 76 female) centenarians, as well as 137 sixty-year-old controls, were analyzed for -1082G/A SNP
      Conclusions
      No significant differences were observed in centenarians and controls
      Indentifier
      -1082G/A
      Reference

        Study 4

        Longevity Association
        Significant
        Population
        Japanese
        Study Design
        -819 T/C SNP was evaluated with age or gender in 500 Japanese persons (mean age: 56.7 years old, range: 19-100)
        Conclusions
        There was a significant association of -819 T/C with age
        Indentifier
        -819C/T
        Reference

          Study 5

          Longevity Association
          Significant
          Population
          Jordanian
          Study Design
          IL-10 -1082 G/A and TNF-alpha-308 G/A were genotyped in 119 randomly selected elderly subjects (41 women and 78 men) with a mean age of 90.2 years and young control subjects of 118 (46 women and 72 men) with a mean age of 31.9 years
          Conclusions
          No significant differences were found in the genotype and allele frequencies of TNF-alpha gene variants between the two groups (P > 0.05). IL-10 genotype and allele frequencies were significantly associated with longevity in men (P < 0.05) but not in women (P < 0.05).
          Indentifier
          -1082G/A
          Reference

            Study 6

            Longevity Association
            Non-significant
            Population
            Bulgarian
            Study Design
            -1082G/A, -819 C/T and -592 C/A SNPs were examined in 17 unrelated elderly (age 65-90 years; 6 males and 11 females), 23 family members (age 18-57 years; 9 males and 14 females, and a control group with 105 randomly selected, matched for geographical dist
            Conclusions
            Genotype -1082G/A, -819 C/C, -592 C/C was positively associated, while genotype -1082A/A, -819 C/T, -592 C/A, was negatively associated with longevity in Bulgarians. The results, however, were not statistically significant.
            Indentifier
            -1082G/A
            Reference

              Study 7

              Longevity Association
              Non-significant
              Population
              Italian (Southern)
              Study Design
              A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
              Conclusions
              After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
              Indentifier
              rs1800896
              Reference

                Study 8

                Longevity Association
                Non-significant
                Population
                Finnish
                Study Design
                250 (52 males and 198 females) nonagenarians and 400 healthy control group (18-60 years old) were examined for 1082 SNP
                Conclusions
                No significant differences relative to longevity were found
                Indentifier
                IL10
                Reference

                  Study 9

                  Longevity Association
                  Significant
                  Population
                  Italian
                  Study Design
                  The -1082G/A, -819C/T and -592C/A proximal promoter SNPs were examined in 190 centenarians (>99 years old, 159 women and 31 men) and in 260 control subjects (99 women and 161 men less than 60 years old)
                  Conclusions
                  The -1082G homozygous genotype, associated with high IL-10 production, was increased in centenarian men but not in centenarian women. No difference was found between centenarians and control subjects regarding the other two SNPs.
                  Indentifier
                  -1082G/A
                  Reference