LongevityMap Gene
Gene details
- HGNC symbol
- IGFBP1
- Aliases
- AFBP; IBP1; PP12; IGF-BP25; hIGFBP-1
- Common name
- insulin like growth factor binding protein 1
- Description
- This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 7p12.3
- UCSC Genome Browser
- View 7p12.3 on the UCSC genome browser
- OMIM
- 146730
- Ensembl
- ENSG00000146678
- UniProt/Swiss-Prot
- IBP1_HUMAN
- Entrez Gene
- 3484
- UniGene
- 642938
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
In other databases
- CellAge
- This gene is present as IGFBP1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Indentifier
- rs4619
- Reference