LongevityMap Gene

Gene details

HGNC symbol
HSPA14 
Aliases
HSP70-4; HSP70L1 
Common name
heat shock protein family A (Hsp70) member 14 
Description
Cytogenetic Location
10p13
UCSC Genome Browser
View 10p13 on the UCSC genome browser
OMIM
610369
Ensembl
ENSG00000187522
UniProt/Swiss-Prot
B0YIZ1_HUMAN
Entrez Gene
51182
UniGene
534169
1000 Genomes
1000 Genomes

Homologs in model organisms

Danio rerio
hspa14
Mus musculus
Hspa14
Rattus norvegicus
Hspa14

Studies (1)

Significant/Non-significant: 1/0

Longevity Association
Significant
Population
Danish, German, Dutch
Study Design
102 SNPs from 16 longevity candidate genes were examined in Danish. 1089 individuals (ages 92.2-93.8, mean age 93.2, 71.3 female) and 736 middle-aged controls (46-55 y, mean age 50.6, 49.6% female) were involved in this case-control study. Then the results were replicated in a German cohort of 1613 individuals (95-110 y, 73.2% female) and 1104 middle-aged controls (mean age 67.2, SD 4.07, 74.3% female). A 11 years study was introduced in Danish cohort to identify the SNPs associated with longevity, then the results were verified in Dutch longitudinal cohort.
Conclusions
Gene-based analysis showed a significant association of variations in HSPA14 with longevity
Indentifier
rs12770830
Reference