LongevityMap Gene

Gene details

HGNC symbol
HLA-DRB5 
Aliases
 
Common name
major histocompatibility complex, class II, DR beta 5 
Description
HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008]
Cytogenetic Location
6p21.32
UCSC Genome Browser
View 6p21.32 on the UCSC genome browser
OMIM
604776
Ensembl
ENSG00000198502
UniProt/Swiss-Prot
DRB5_HUMAN
Entrez Gene
3127
UniGene
485130
1000 Genomes
1000 Genomes

Homologs in model organisms

Danio rerio
mhc2dab
Danio rerio
si:dkey-33b17.3
Danio rerio
zgc:103700
Danio rerio
mhc2dbb
Danio rerio
mhc2dab
Danio rerio
zgc:103700
Danio rerio
si:zfos-2070c2.3
Danio rerio
mhc2dab
Danio rerio
si:busm1-228j01.6
Danio rerio
si:busm1-228j01.4
Danio rerio
mhc2dab
Danio rerio
si:ch73-158p21.3
Danio rerio
si:busm1-194e12.12
Danio rerio
si:busm1-228j01.4
Danio rerio
si:busm1-104n07.3
Mus musculus
H2-Eb2
Mus musculus
H2-Eb1
Rattus norvegicus
RT1-Db2
Rattus norvegicus
RT1-Db1

Studies (1)

Significant/Non-significant: 0/1

Longevity Association
Non-significant
Population
Dutch
Study Design
964 inhabitants aged 85 years and over and 2444 young controls, aged 20-35 years, with an identical ethnic and demographic background were examined
Conclusions
Without correcting for multiple testing, HLA-DR5 was higher in the group of 85 years and over, as compared to the control group
Indentifier
HLA-DRB5
Reference