LongevityMap Gene
Gene details
- HGNC symbol
- HLA-DRB5
- Aliases
- Common name
- major histocompatibility complex, class II, DR beta 5
- Description
- HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 6p21.32
- UCSC Genome Browser
- View 6p21.32 on the UCSC genome browser
- OMIM
- 604776
- Ensembl
- ENSG00000198502
- UniProt/Swiss-Prot
- DRB5_HUMAN
- Entrez Gene
- 3127
- UniGene
- 485130
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- mhc2dab
- Danio rerio
- si:dkey-33b17.3
- Danio rerio
- zgc:103700
- Danio rerio
- mhc2dbb
- Danio rerio
- mhc2dab
- Danio rerio
- zgc:103700
- Danio rerio
- si:zfos-2070c2.3
- Danio rerio
- mhc2dab
- Danio rerio
- si:busm1-228j01.6
- Danio rerio
- si:busm1-228j01.4
- Danio rerio
- mhc2dab
- Danio rerio
- si:ch73-158p21.3
- Danio rerio
- si:busm1-194e12.12
- Danio rerio
- si:busm1-228j01.4
- Danio rerio
- si:busm1-104n07.3
- Mus musculus
- H2-Eb2
- Mus musculus
- H2-Eb1
- Rattus norvegicus
- RT1-Db2
- Rattus norvegicus
- RT1-Db1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Dutch
- Study Design
- 964 inhabitants aged 85 years and over and 2444 young controls, aged 20-35 years, with an identical ethnic and demographic background were examined
- Conclusions
- Without correcting for multiple testing, HLA-DR5 was higher in the group of 85 years and over, as compared to the control group
- Indentifier
- HLA-DRB5
- Reference