LongevityMap Gene

Gene details

HGNC symbol
GSTT1 
Aliases
 
Common name
glutathione S-transferase theta 1 
Description
The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Cytogenetic Location
22q11.23
UCSC Genome Browser
View 22q11.23 on the UCSC genome browser
OMIM
600436
Ensembl
UniProt/Swiss-Prot
A0A0G2JRN4_HUMAN
Entrez Gene
2952
UniGene
268573
1000 Genomes
1000 Genomes

Homologs in model organisms

Danio rerio
gstt1b
Mus musculus
Gstt1
Rattus norvegicus
Gstt1

Studies (4)

Significant/Non-significant: 3/1

Study 1

Longevity Association
Non-significant
Population
German
Study Design
Deletion was examined in 205 octogenarians and a reference group of 294 persons aged less than 80 years
Conclusions
Octogenarians had slightly less GSTT1 deficient genotypes
Indentifier
GSTT1
Reference

    Study 2

    Longevity Association
    Significant
    Population
    Danish
    Study Design
    Deletion polymorphism was examined in a longitudinal study of 681 elderly Danish twins (234 men and 447 women)
    Conclusions
    Both heterozygosity and homozygosity for the GSTT1 functional gene were associated with a moderate but significant increased mortality in women
    Indentifier
    GSTT1
    Reference

      Study 3

      Longevity Association
      Significant
      Population
      Italian (Northern)
      Study Design
      GSTT1 (Glutathione S-transferase theta 1) deletion and the simultaneous presence of the three p53 polymorphisms were examined in 66 nonagenarians and centenarians in good health and in a sample of 150 young healthy volunteers of the same ethnic group
      Conclusions
      No significant differences were found for individual genes. However, the absence of any p53 polymorphisms and of GSTT1 deletion, and the simultaneous presence of the three p53 polymorphisms and of GSTT1 deletion, were much more frequent in young subjects than in centenarians (41.5% versus 26.9% and 8.8% versus 3.8%, respectively).
      Indentifier
      GSTT1
      Reference

        Study 4

        Longevity Association
        Significant
        Population
        Italian (Northern)
        Study Design
        Deletion was examined in 94 nonagenarians and centenarians and 418 control subjects of younger age
        Conclusions
        A significant difference in the proportion of nonagenarians and centenarians homozygotes for the deletion was observed in comparison to control subjects
        Indentifier
        GSTT1
        Reference