LongevityMap Gene

Gene details

HGNC symbol: GSTM1
Aliases: MU; H-B; GST1; GTH4; GTM1; MU-1; GSTM1-1; GSTM1a-1a; GSTM1b-1b
Common name: glutathione S-transferase mu 1
Description: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]
Cytogenetic Location: 1p13.3
UCSC Genome Browser: View 1p13.3 on the UCSC genome browser
OMIM: 138350
Ensembl: ENSG00000134184
UniProt/Swiss-Prot: GSTM1_HUMAN
Entrez Gene: 2944
UniGene: 301961
1000 Genomes: 1000 Genomes

Homologs in model organisms

Caenorhabditis elegans: gst-41
Caenorhabditis elegans: gst-1
Caenorhabditis elegans: gst-25
Caenorhabditis elegans: gst-23
Danio rerio: gstm.3
Danio rerio: gstm.1
Danio rerio: gstm.2
Mus musculus: Gm6665
Mus musculus: Gstm7
Mus musculus: Gstm4
Mus musculus: Gstm3
Mus musculus: Gstm6
Mus musculus: Gstm2
Mus musculus: Gstm1
Rattus norvegicus: Gstm6l
Rattus norvegicus: Gstm4
Rattus norvegicus: Gstm6
Rattus norvegicus: Gstm6l
Rattus norvegicus: Gstm7
Rattus norvegicus: Gstm7
Rattus norvegicus: Gstm1
Rattus norvegicus: Gstm3

Studies (4)

Significant/Non-significant: 0/4

Study 1

Longevity Association

Non-significant

Population

Study Design

The GSTM1 deletion was examined in 552 centenarians and 243 controls aged 20-70 years

Conclusions

No significant difference was found between centenarian and control subjects

Indentifier

Reference

Study 2

Longevity Association

Non-significant

Population

Italian (Northern)

Study Design

GSTM1 deletion was examined in 94 nonagenarians and centenarians and in 418 control subjects of younger age

Conclusions

No association with longevity was found

Indentifier

Reference

Study 3

Longevity Association

Non-significant

Population

Study Design

GSTM1 deletion was examined in 205 octogenarians and a reference group of 294 persons aged less than 80 years

Conclusions

Octogenarians had marginally significant more GSTM1 negatives

Indentifier

Reference

Study 4

Longevity Association

Non-significant

Population

Study Design

The GSTM1 deletion polymorphism was examined in a longitudinal study of 681 elderly Danish twins (234 men and 447 women)

Conclusions

A non-significant trend for carriage of two copies of the GSTM1 functional gene was found

Indentifier

Reference