LongevityMap Gene

Gene details

HGNC symbol
GRIP1 
Aliases
GRIP 
Common name
glutamate receptor interacting protein 1 
Description
This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]
Cytogenetic Location
12q14.3
UCSC Genome Browser
View 12q14.3 on the UCSC genome browser
OMIM
604597
Ensembl
ENSG00000155974
UniProt/Swiss-Prot
GRIP1_HUMAN
Entrez Gene
23426
UniGene
505946
1000 Genomes
1000 Genomes

Homologs in model organisms

Danio rerio
grip1
Drosophila melanogaster
Grip
Mus musculus
Grip1
Rattus norvegicus
Grip1

Studies (1)

Significant/Non-significant: 0/1

Longevity Association
Non-significant
Population
Italian
Study Design
Genome-wide association study on 410 long-living individuals (age range, 90–109 years) and 553 young control individuals (age range, 18–48 years) using 318,237 SNPs. An independent population with 116 long-lived individuals and 160 controls was used for replication purposes.
Conclusions
A total of 67 SNPs were identified with an indication of potentially being associated with longevity (p < 1 × 10−4), though 66 were not further validated
Indentifier
rs969845
Reference