LongevityMap Gene
Gene details
- HGNC symbol
- GRB2
- Aliases
- ASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2
- Common name
- growth factor receptor bound protein 2
- Description
- The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 17q25.1
- UCSC Genome Browser
- View 17q25.1 on the UCSC genome browser
- OMIM
- 108355
- Ensembl
- ENSG00000177885
- UniProt/Swiss-Prot
- B0LPF3_HUMAN
- Entrez Gene
- 2885
- UniGene
- 444356
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- sem-5
- Danio rerio
- grb2a
- Danio rerio
- grb2b
- Drosophila melanogaster
- drk
- Mus musculus
- Grb2
- Rattus norvegicus
- Grb2
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as sem-5
- GenAge human genes
- This gene is present as GRB2
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Indentifier
- rs2053158
- Reference