LongevityMap Gene

Gene details

HGNC symbol
GNA14 
Aliases
 
Common name
G protein subunit alpha 14 
Description
This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant activation of phospholipase C-beta and its downstream effectors.[provided by RefSeq, Feb 2009]
Cytogenetic Location
9q21.2
UCSC Genome Browser
View 9q21.2 on the UCSC genome browser
OMIM
604397
Ensembl
ENSG00000156049
UniProt/Swiss-Prot
GNA14_HUMAN
Entrez Gene
9630
UniGene
657795
1000 Genomes
1000 Genomes

Homologs in model organisms

Drosophila melanogaster
Galpha49B
Mus musculus
Gna14
Rattus norvegicus
Gna14
Saccharomyces cerevisiae
GPA1

Studies (1)

Significant/Non-significant: 0/1

Longevity Association
Non-significant
Population
Caucasians
Study Design
Meta-analysis of GWAS in Caucasians from four prospective cohort studies: the Age, Gene/Environment Susceptibility-Reykjavik Study, the Cardiovascular Health Study, the Framingham Heart Study, and the Rotterdam Study participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Longevity was defined as survival to age 90 years or older (n = 1,836); the comparison group comprised cohort members who died between the ages of 55 and 80 years (n = 1,955).
Conclusions
There were 273 single-nucleotide polymorphism (SNP) associations with p < .0001, but none reached significance after correcting for multiple testing
Indentifier
rs13288161
Reference