LongevityMap Gene
Gene details
- HGNC symbol
- GNA14
- Aliases
- Common name
- G protein subunit alpha 14
- Description
- This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant activation of phospholipase C-beta and its downstream effectors.[provided by RefSeq, Feb 2009]
- Cytogenetic Location
- 9q21.2
- UCSC Genome Browser
- View 9q21.2 on the UCSC genome browser
- OMIM
- 604397
- Ensembl
- ENSG00000156049
- UniProt/Swiss-Prot
- GNA14_HUMAN
- Entrez Gene
- 9630
- UniGene
- 657795
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as GPA2
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as GPA2
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Caucasians
- Study Design
- Meta-analysis of GWAS in Caucasians from four prospective cohort studies: the Age, Gene/Environment Susceptibility-Reykjavik Study, the Cardiovascular Health Study, the Framingham Heart Study, and the Rotterdam Study participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Longevity was defined as survival to age 90 years or older (n = 1,836); the comparison group comprised cohort members who died between the ages of 55 and 80 years (n = 1,955).
- Conclusions
- There were 273 single-nucleotide polymorphism (SNP) associations with p < .0001, but none reached significance after correcting for multiple testing
- Indentifier
- rs13288161
- Reference