LongevityMap Gene

Gene details

HGNC symbol
GADD45A 
Aliases
DDIT1; GADD45 
Common name
growth arrest and DNA damage inducible alpha 
Description
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]
Cytogenetic Location
1p31.3
UCSC Genome Browser
View 1p31.3 on the UCSC genome browser
OMIM
126335
Ensembl
ENSG00000116717
UniProt/Swiss-Prot
A5JUZ3_HUMAN
Entrez Gene
1647
UniGene
80409
1000 Genomes
1000 Genomes

Homologs in model organisms

Danio rerio
gadd45ab
Danio rerio
gadd45aa
Mus musculus
Gadd45a
Rattus norvegicus
Gadd45a

In other databases

CellAge gene expression

Studies (1)

Significant/Non-significant: 0/1

Longevity Association
Non-significant
Population
Italian (Southern)
Study Design
A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
Conclusions
After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
Indentifier
rs532446
Reference