LongevityMap Gene

Gene details

HGNC symbol
FMN2 
Aliases
 
Common name
formin 2 
Description
This gene is a member of the formin homology protein family. The encoded protein is thought to have essential roles in organization of the actin cytoskeleton and in cell polarity. Mutations in this gene have been associated with mental retardation autosomal recessive 47 (MRT47). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
Cytogenetic Location
1q43
UCSC Genome Browser
View 1q43 on the UCSC genome browser
OMIM
606373
Ensembl
ENSG00000155816
UniProt/Swiss-Prot
FMN2_HUMAN
Entrez Gene
56776
UniGene
24889
1000 Genomes
1000 Genomes

Homologs in model organisms

Drosophila melanogaster
capu
Mus musculus
Fmn2

Studies (1)

Significant/Non-significant: 0/1

Longevity Association
Non-significant
Population
Italian
Study Design
Genome-wide association study on 410 long-living individuals (age range, 90–109 years) and 553 young control individuals (age range, 18–48 years) using 318,237 SNPs. An independent population with 116 long-lived individuals and 160 controls was used for replication purposes.
Conclusions
A total of 67 SNPs were identified with an indication of potentially being associated with longevity (p < 1 × 10−4), though 66 were not further validated
Indentifier
rs12088486
Reference