LongevityMap Gene

Gene details

HGNC symbol
FAM19A1 
Aliases
TAFA1; TAFA-1 
Common name
family with sequence similarity 19 member A1, C-C motif chemokine like 
Description
This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]
Cytogenetic Location
3p14.1
UCSC Genome Browser
View 3p14.1 on the UCSC genome browser
OMIM
Ensembl
ENSG00000183662
UniProt/Swiss-Prot
F19A1_HUMAN
Entrez Gene
407738
UniGene
655061
1000 Genomes
1000 Genomes

Homologs in model organisms

Danio rerio
CR631124.1
Mus musculus
Fam19a1
Rattus norvegicus
Fam19a1

Studies (1)

Significant/Non-significant: 0/1

Longevity Association
Non-significant
Population
American, English, Irish
Study Design
10 late-onset Alzheimer's disease genes were tested for association with human aging in the dataset (1385 samples with documented age at death, age range: 58–108 years; mean age at death: 80.2 years) using the most significant SNPs found in the previous studies. A set of 41 tentative SNPs span the genome were identified in this study.
Conclusions
Some signals were at best tentative but may merit study in larger sample sets
Indentifier
rs17047650
Reference