LongevityMap Gene
Gene details
- HGNC symbol
- EIF4E
- Aliases
- CBP; EIF4F; AUTS19; EIF4E1; eIF-4E; EIF4EL1
- Common name
- eukaryotic translation initiation factor 4E
- Description
- The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
- Cytogenetic Location
- 4q23
- UCSC Genome Browser
- View 4q23 on the UCSC genome browser
- OMIM
- 133440
- Ensembl
- ENSG00000151247
- UniProt/Swiss-Prot
- D6RBW1_HUMAN
- Entrez Gene
- 1977
- UniGene
- 13211
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- ife-1
- Caenorhabditis elegans
- ife-3
- Caenorhabditis elegans
- ife-2
- Caenorhabditis elegans
- ife-5
- Danio rerio
- eif4eb
- Danio rerio
- eif4ea
- Drosophila melanogaster
- eIF4E-5
- Drosophila melanogaster
- eIF4E-4
- Drosophila melanogaster
- eIF4E-7
- Drosophila melanogaster
- eIF-4E
- Drosophila melanogaster
- eIF4E-3
- Drosophila melanogaster
- eIF4E-6
- Mus musculus
- Eif4e
- Rattus norvegicus
- Eif4e
- Saccharomyces cerevisiae
- CDC33
In other databases
- GenAge model organism genes
- CellAge
- This gene is present as EIF4E
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- Dutch
- Study Design
- 1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls
- Conclusions
- As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing
- Indentifier
- EIF4E
- Reference