LongevityMap Gene

Gene details

HGNC symbol
EGFR 
Aliases
ERBB; HER1; mENA; ERBB1; PIG61; NISBD2 
Common name
epidermal growth factor receptor 
Description
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016]
Cytogenetic Location
7p11.2
UCSC Genome Browser
View 7p11.2 on the UCSC genome browser
OMIM
131550
Ensembl
ENSG00000146648
UniProt/Swiss-Prot
B7Z2I3_HUMAN
Entrez Gene
1956
UniGene
488293
1000 Genomes
1000 Genomes

Homologs in model organisms

Mus musculus
Egfr
Rattus norvegicus
Egfr

In other databases

GenAge human genes
  • This gene is present as EGFR

Studies (1)

Significant/Non-significant: 1/0

Longevity Association
Significant
Population
Korean
Study Design
463 biomarkers in 176 diesase associated genes were examined in 137 long lived individuals (>90 y, 59.1% female, 96.73 ± 3.97 y) and 213 young controls (12-14 y, 39.4% female, 12.93 ± 0.80)
Conclusions
EGFR was associated with longevity (P = 0.003) after correcting for multiple hypothesis testing
Indentifier
rs2072454
Reference