LongevityMap Gene
Gene details
- HGNC symbol
- EEF1AKMT3
- Aliases
- FAM119B; METTL21B
- Common name
- EEF1A lysine methyltransferase 3
- Description
- Cytogenetic Location
- 12q14.1
- UCSC Genome Browser
- View 12q14.1 on the UCSC genome browser
- OMIM
- 615258
- Ensembl
- ENSG00000123427
- UniProt/Swiss-Prot
- MT21B_HUMAN
- Entrez Gene
- 25895
- UniGene
- 632720
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- C42C1.13
- Mus musculus
- Mettl21b
- Rattus norvegicus
- Mettl21b
- Saccharomyces cerevisiae
- 855707
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- American
- Study Design
- A genome-wide linkage scan was performed for healthy aging in family study data, followed by fine-mapping by association in a separate population. A frailty index, called FI34, was introduced as a quantitative measure of healthy aging.
- Conclusions
- A single linkage peak was found on chromosome 12 in the genome-wide linkage scan. Fine-scale association mapping identified three sites associated with healthy aging in intergenic regions at 12q13-14.
- Indentifier
- rs923829
- Reference