LongevityMap Gene

Gene details

HGNC symbol
DNM3 
Aliases
Dyna; III 
Common name
dynamin 3 
Description
This gene encodes a member of a family of guanosine triphosphate (GTP)-binding proteins that associate with microtubules and are involved in vesicular transport. The encoded protein functions in the development of megakaryocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Cytogenetic Location
1q24.3
UCSC Genome Browser
View 1q24.3 on the UCSC genome browser
OMIM
611445
Ensembl
ENSG00000197959
UniProt/Swiss-Prot
DYN3_HUMAN
Entrez Gene
26052
UniGene
654775
1000 Genomes
1000 Genomes

Homologs in model organisms

Caenorhabditis elegans
dyn-1
Danio rerio
dnm3a
Danio rerio
CABZ01092282.1
Drosophila melanogaster
shi
Mus musculus
Dnm3
Rattus norvegicus
Dnm3
Saccharomyces cerevisiae
VPS1
Saccharomyces cerevisiae
DNM1

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as DNM1

Studies (1)

Significant/Non-significant: 0/1

Longevity Association
Non-significant
Population
American (Caucasian and African-American)
Study Design
The baseline levels of sCD14 (soluble form of CD14) were measured in 5888 European-American and black adults aged 65 years and older from the Cardiovascular Health Study. A genome-wide cardiovascular disease candidate gene-centric association with sCD14 was conducted separately in the European-Americans (n=2952) and blacks (n=528). Finally, the ability of sCD14 and its main genetic determinants to predict incident CVD and mortality during follow-up was assessed.
Conclusions
sCD14 was positively correlated with cardio-metabolic risk factors and with subclinical measures of vascular disease, and was also inversely correlated with body mass index (all P<0.001). In European Americans the minor allele at the index SNP rs5744441 was associated with lower sCD14, the C allele of index SNP rs1063412 was associated with lower sCD14. In Blacks the index SNP rs778584 was associated with higher sCD14. In the fully adjusted model, sCD14 was associated with death because of cardiovascular causes (hazard ratio=1.13, P=0.001) and death because of noncardiovascular causes (hazard ratio=1.11, P=0.001). CD14 independently predicts risk mortality in older adults. However, no SNPs were associated with risk of mortality when corrected for multiple hypothesis testing.
Indentifier
rs1011731
Reference