LongevityMap Gene

Gene details

HGNC symbol
DEPTOR 
Aliases
DEP.6; DEPDC6 
Common name
DEP domain containing MTOR interacting protein 
Description
Cytogenetic Location
8q24.12
UCSC Genome Browser
View 8q24.12 on the UCSC genome browser
OMIM
612974
Ensembl
ENSG00000155792
UniProt/Swiss-Prot
DPTOR_HUMAN
Entrez Gene
64798
UniGene
112981
1000 Genomes
1000 Genomes

Homologs in model organisms

Danio rerio
deptor
Mus musculus
Deptor
Rattus norvegicus
Deptor

Studies (1)

Significant/Non-significant: 1/0

Longevity Association
Significant
Population
Dutch
Study Design
1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls
Conclusions
As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing
Indentifier
DEPTOR
Reference