LongevityMap Gene
Gene details
- HGNC symbol
- CYP2C18
- Aliases
- CPCI; CYP2C; CYP2C17; P450IIC17; P450-6B/29C
- Common name
- cytochrome P450 family 2 subfamily C member 18
- Description
- This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 10q23.33
- UCSC Genome Browser
- View 10q23.33 on the UCSC genome browser
- OMIM
- 601131
- Ensembl
- ENSG00000108242
- UniProt/Swiss-Prot
- CP2CI_HUMAN
- Entrez Gene
- 1562
- UniGene
- 511872
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- si:zfos-411a11.2
- Danio rerio
- cyp2y3
- Mus musculus
- Cyp2c55
- Rattus norvegicus
- LOC100361492
- Rattus norvegicus
- Cyp2c24
- Rattus norvegicus
- Cyp2c11
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- German
- Study Design
- Genotyping of 56 single nucleotide polymorphisms located in the CYP2C gene family was performed for 1384 unrelated long-lived individuals (age range: 95-109 years, mean: 98.8 years), including 616 centenarians (mean age: 101.3 years), and 945 younger controls (age range: 60-75 years, mean: 66.9 years). The gender ratio was 73% females versus 27% males.
- Conclusions
- None of the tested single nucleotide polymorphisms showed a significant association with the longevity phenotype at the allele, genotype, or haplotype level
- Indentifier
- rs10736086
- Reference