LongevityMap Gene

Gene details

HGNC symbol
CETP 
Aliases
BPIFF; HDLCQ10 
Common name
cholesteryl ester transfer protein 
Description
The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
Cytogenetic Location
16q13
UCSC Genome Browser
View 16q13 on the UCSC genome browser
OMIM
118470
Ensembl
ENSG00000087237
UniProt/Swiss-Prot
A0A0S2Z3F6_HUMAN
Entrez Gene
1071
UniGene
89538
1000 Genomes
1000 Genomes

Homologs in model organisms

Danio rerio
cetp

In other databases

GenAge human genes
  • This gene is present as CETP

Studies (9)

Significant/Non-significant: 4/5

Study 1

Longevity Association
Significant
Population
Ashkenazi Jewish
Study Design
The I405V polymorphism distribution was examined in 213 Ashkenazi Jews with exceptional longevity (mean [SD] age, 98.2 [5.3] years), their offspring (n = 216; mean [SD] age, 68.3 [6.7] years) and in an age-matched control group of Ashkenazi Jews (n = 258) plus in participants from the Framingham Offspring Study (n = 589)
Conclusions
Probands with exceptional longevity showed an increased frequency of homozygosity for the 405 valine allele (VV genotype) compared with controls
Indentifier
I405V
Reference

    Study 2

    Longevity Association
    Non-significant
    Population
    Italian
    Study Design
    The I405V polymorphism was examined in 175 Italian centenarians and, as a control group, 189 sex-matched healthy individuals
    Conclusions
    No association with longevity was found
    Indentifier
    I405V
    Reference

      Study 3

      Longevity Association
      Significant
      Population
      Ashkenazi Jewish
      Study Design
      Case-control study for phenotype and genotype of exceptional longevity in a genetically homogenous population (Ashkenazi Jews, 80% female), and their offspring (320 subjects, 55% female). An age-matched control group of Ashkenazi Jews (n = 258) was used as control group.
      Conclusions
      A functional CETP variant contributed to the better health performance and thus exceptional longevity (P < 0.05).
      Indentifier
      CETP
      Reference

        Study 4

        Longevity Association
        Non-significant
        Population
        Chinese
        Study Design
        The distribution of CETP*V and APOE*4 were analyzed in 372 oldest-old women (aged 80-109) and 340 controls (aged 20-58).
        Conclusions
        No contribution of CETP I405V to longevity was found.
        Indentifier
        I405V
        Reference

          Study 5

          Longevity Association
          Non-significant
          Population
          Greek
          Study Design
          307 individuals (190 nonagenarians, 12 centenarians and 105 middle-aged controls) were genotyped for ACE, NFkB, and CETP genetic variants
          Conclusions
          No significant difference were found between case group and control group for NFkB and CETP
          Indentifier
          rs708272
          Reference

            Study 6

            Longevity Association
            Significant
            Population
            Danish, German, Dutch
            Study Design
            102 SNPs from 16 longevity candidate genes were examined in Danish. 1089 individuals (ages 92.2-93.8, mean age 93.2, 71.3 female) and 736 middle-aged controls (46-55 y, mean age 50.6, 49.6% female) were involved in this case-control study. Then the results were replicated in a German cohort of 1613 individuals (95-110 y, 73.2% female) and 1104 middle-aged controls (mean age 67.2, SD 4.07, 74.3% female). A 11 years study was introduced in Danish cohort to identify the SNPs associated with longevity, then the results were verified in Dutch longitudinal cohort.
            Conclusions
            The minor allele frequency of rs9923854 in CETP was significantly associated with longevity. Haplotype case–control comparisons identified two haplotypes associated with longevity. Gene-based analysis confirmed the significant association of variations in CETP with longevity. The association of rs9923854 was borderline in the German population.
            Indentifier
            rs5882
            Reference

              Study 7

              Longevity Association
              Significant
              Population
              Ashkenazi Jewish
              Study Design
              205 centenarians (141 females, median age = 97 years and 64 males, median age = 97 years), their offspring (n = 145 total, 80 females, median age = 69 years and 65 males median age = 68 years), and 288 controls (167 females, median age = 74 years and 121 males, median age = 75 years) were examined for the association between genotype and longevity
              Conclusions
              A U-shape pattern of MTP CC genotype frequency with aging was observed. The CC was a buffered-deleterious genotype in the case group. In the control group without longevity genes, CC genotype included poorer survivorship.
              Indentifier
              rs5882
              Reference

                Study 8

                Longevity Association
                Non-significant
                Population
                American of Japanese origin
                Study Design
                Total mortality, cause-specific mortality, and healthy survival were evaluated for associations with CETP genetic variants common in 3562 Japanese-American men from Honolulu Heart Program
                Conclusions
                No association was found between rs2303790 and mortality (p =.38). There was a trend for lower mortality for men with the Int 14A variant in rs5742907, though it failed to reach statistical significance.
                Indentifier
                rs5742907
                Reference

                  Study 9

                  Longevity Association
                  Non-significant
                  Population
                  Japanese
                  Study Design
                  Polymorphisms (mutations in intron 14 and exon 15, and Taq1B) were examined in 256 centenarians and 190 healthy younger controls (22-65 years old)
                  Conclusions
                  The allelic frequencies did not differ between the two groups
                  Indentifier
                  CETP
                  Reference