LongevityMap Gene

Gene details

HGNC symbol
CDKAL1 
Aliases
 
Common name
CDK5 regulatory subunit associated protein 1 like 1 
Description
The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes. [provided by RefSeq, May 2010]
Cytogenetic Location
6p22.3
UCSC Genome Browser
View 6p22.3 on the UCSC genome browser
OMIM
611259
Ensembl
ENSG00000145996
UniProt/Swiss-Prot
CDKAL_HUMAN
Entrez Gene
54901
UniGene
657604
1000 Genomes
1000 Genomes

Homologs in model organisms

Caenorhabditis elegans
Y92H12BL.1
Danio rerio
cdkal1
Drosophila melanogaster
CG6550
Mus musculus
Cdkal1

Studies (1)

Significant/Non-significant: 0/1

Longevity Association
Non-significant
Population
Dutch
Study Design
A set of alleles associated with age-related diseases was tested for association with human longevity in 723 nonagenarian siblings and 721 unrelated younger controls plus 979 singleton individuals >85 years of age and 1,167 younger controls
Conclusions
No differences were observed in disease risk allele frequency between long-lived individuals and controls. No individual allele was significantly associated with survival to old age after controlling for multiple testing.
Indentifier
rs7754840
Reference