LongevityMap Gene

Gene details

HGNC symbol
CAT 
Aliases
 
Common name
catalase 
Description
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]
Cytogenetic Location
11p13
UCSC Genome Browser
View 11p13 on the UCSC genome browser
OMIM
115500
Ensembl
ENSG00000121691
UniProt/Swiss-Prot
CATA_HUMAN
Entrez Gene
847
UniGene
502302
1000 Genomes
1000 Genomes

Homologs in model organisms

Caenorhabditis elegans
ctl-3
Danio rerio
cat
Drosophila melanogaster
CG9314
Mus musculus
Cat
Rattus norvegicus
Cat
Saccharomyces cerevisiae
CTA1
Schizosaccharomyces pombe
cta1

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Cat
  • A homolog of this gene for Saccharomyces cerevisiae is present as CTA1
GenAge human genes
  • This gene is present as CAT

Studies (3)

Significant/Non-significant: 0/3

Study 1

Longevity Association
Non-significant
Population
Danish
Study Design
The -262C/T polymorphism was examined in 2223 Danish individuals aged 45-93 years
Conclusions
The -262C/T polymorphism was not associated with survival
Indentifier
-262C/T
Reference

    Study 2

    Longevity Association
    Non-significant
    Population
    Italian (Southern)
    Study Design
    A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
    Conclusions
    After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
    Indentifier
    rs1001179
    Reference

      Study 3

      Longevity Association
      Non-significant
      Population
      Danish
      Study Design
      38 genes (311 SNPs) belonging to pro-antioxidant pathways were investigated for the association with physical and cognitive performances in a Cohort of 1089 Danish nonagenarians. For each gene analyzed in the pro-antioxidant pathway, the influence on longitudinal survival was tested.
      Conclusions
      No gene found associated with a functional phenotype showed a corresponding association with survival in the whole cohort. NDUFS1, TXNRD1, SOD2 and UCP3 were found significantly associated with lifespan in the female cohort. No association with survival was reported in males for genes belonging to the pro-oxidant pathway here analyzed.
      Indentifier
      rs10488736
      Reference