LongevityMap Gene

Gene details

HGNC symbol
ATP5J2-PTCD1 
Aliases
 
Common name
ATP5J2-PTCD1 readthrough 
Description
This locus represents naturally occurring read-through transcription between the ATP5J2 (ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2) and PTCD1 (pentatricopeptide repeat domain 1) genes on chromosome 7. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Nov 2010]
Cytogenetic Location
7q22.1
UCSC Genome Browser
View 7q22.1 on the UCSC genome browser
OMIM
Ensembl
ENSG00000248919
UniProt/Swiss-Prot
B4DJ38_HUMAN
Entrez Gene
100526740
UniGene
632313
1000 Genomes
1000 Genomes

Homologs in model organisms

No homologs found

Studies (1)

Significant/Non-significant: 0/1

Longevity Association
Non-significant
Population
Dutch
Study Design
Genome-wide association study in 403 unrelated nonagenarians from long-living families and 1670 younger controls. Strongest candidates were then investigated in a meta-analysis of 4149 nonagenarian cases and 7582 younger controls.
Conclusions
No SNP reached significance in the GWAS but 62 SNPs, many in genes, had an indicative association with survival into old age. Of these 62 SNPs then studied in the meta-analysis, 61 were not significant.
Indentifier
rs2003499
Reference