LongevityMap Gene

Gene details

HGNC symbol
APOA4 
Aliases
 
Common name
apolipoprotein A4 
Description
Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]
Cytogenetic Location
11q23.3
UCSC Genome Browser
View 11q23.3 on the UCSC genome browser
OMIM
107690
Ensembl
ENSG00000110244
UniProt/Swiss-Prot
Entrez Gene
337
UniGene
1247
1000 Genomes
1000 Genomes

Homologs in model organisms

No homologs found

Studies (3)

Significant/Non-significant: 1/2

Study 1

Longevity Association
Non-significant
Population
French
Study Design
Glutamine (CAG) to histidine (CAT) substitution at codon 360 was examined in 120 Alzheimer patients (88 females, 32 males) and 119 presumed-healthy elderly subjects (62 females, 57 males)
Conclusions
The frequency of apoAIV alleles was not significantly different between Alzheimer patients and the elderly control group. However, in both groups, apoAIV (360:His) allele frequency was higher than in the general population.
Indentifier
APOA4
Reference

    Study 2

    Longevity Association
    Significant
    Population
    Italian
    Study Design
    Two restriction polymorphisms, HinfI347 (Thr347/Ser) and Fnu4HI360 (Gln360/His), and a VNTR (alleles 3, 4) at the 3 region of the APOA4 gene were examined in 71 centenarians (18 men and 53 women, 100-107 years of age, mean 102.3 years) and 100 unrelated adults (21 men and 79 women, 19-59 years of age, mean 35.7 years)
    Conclusions
    The Hinf347 genotype distribution was significantly different in centenarians
    Indentifier
    Hinf347
    Reference

      Study 3

      Longevity Association
      Non-significant
      Population
      Italian (Southern)
      Study Design
      APOA4-HincII-RFLP (Asp127/Ser127) polymorphism was examined in a healthy population with 304 subjects aged 18-45 years, 267 subjects aged 46-80 years and 229 subjects aged 81-109 years (including 184 subjects, 43 males and 141 females, older than 100 years)
      Conclusions
      No significant differences relative to longevity were found
      Indentifier
      APOA4-HincII-RFLP
      Reference