LongevityMap variant group
- Longevity Association
- Significant
- Population
- Danish
- Study Design
- 38 genes (311 SNPs) belonging to pro-antioxidant pathways were investigated for the association with physical and cognitive performances in a Cohort of 1089 Danish nonagenarians. For each gene analyzed in the pro-antioxidant pathway, the influence on longitudinal survival was tested.
- Conclusions
- NDUFS1, TXNRD1, SOD2 and UCP3 were found significantly associated with lifespan in the female cohort. This result is consistent with their associations with physical functioning and suggests that the variability of genes in the pro-antioxidant pathway can influence survival through an effect on physical performances, at least in the analyzed cohort.
- HGNC symbol
- NDUFS1
- Aliases
- CI-75k; CI-75Kd; PRO1304
- Common name
- NADH:ubiquinone oxidoreductase core subunit S1
- Description
- The protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Mutations in this gene are associated with complex I deficiency. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
- Other longevity studies of this gene
- 4
- OMIM
- 157655
- Ensembl
- ENSG00000023228
- UniProt/Swiss-Prot
- E5KRK5_HUMAN
- Entrez Gene
- 4719
- UniGene
- 471207
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- nuo-5
- Danio rerio
- ndufs1
- Drosophila melanogaster
- ND75
- Mus musculus
- Ndufs1
- Rattus norvegicus
- Ndufs1
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as nuo-5
- A homolog of this gene for Drosophila melanogaster is present as ND75
Dato et al. (2014)
Other variants which are also part of this study