LongevityMap variant group
Entry Details
- Longevity Association
- Non-significant
- Population
- American (Amish)
- Study Design
- 630,309 SNPs were examined by genome-wide linkage and association study among 74 successfully aged (35% female, mean age 81.82 years) and 189 'normally aged' (67% female mean age 83.74 years) Amish adults over age 80
- Conclusions
- Several SNPs had strong, but not genome-wide, significant evidence for association (p < 1.00 × 10−5). Several of these markers are on chromosome 6 within the FRA6E region and associated with SA (minimum p = 2.89 × 10−6). These findings suggest potentially novel genes in the 6q25-q27 region linked and associated with successful aging in the Amish.
Variants (23)
- Gene summary:
- LOC105378093 (7)
- LOC107986820 (1)
- PRKN (15)
LOC105378093
Gene details
- HGNC symbol
- LOC105378093
- Aliases
- Common name
- uncharacterized LOC105378093
- Description
- Other longevity studies of this gene
- 6
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 105378093
- UniGene
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
LOC107986820
Gene details
- HGNC symbol
- LOC107986820
- Aliases
- Common name
- uncharacterized LOC107986820
- Description
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 107986820
- UniGene
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
PRKN
Gene details
- HGNC symbol
- PRKN
- Aliases
- PDJ; AR-JP; LPRS2; PARK2
- Common name
- parkin RBR E3 ubiquitin protein ligase
- Description
- The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 15
- OMIM
- 602544
- Ensembl
- ENSG00000185345
- UniProt/Swiss-Prot
- PRKN2_HUMAN
- Entrez Gene
- 5071
- UniGene
- 132954
- HapMap
- View on HapMap
Homologs in model organisms
In other databases
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as park