LongevityMap variant group

Entry Details

Longevity Association
Significant
Population
Korean
Study Design
463 biomarkers in 176 diesase associated genes were examined in 137 long lived individuals (>90 y, 59.1% female, 96.73 ± 3.97 y) and 213 young controls (12-14 y, 39.4% female, 12.93 ± 0.80)
Conclusions
PAX4 was associated with longevity (P = 0.008) after correcting for multiple hypothesis testing

Variants (3)

1.
Identifier
rs327519
Cytogenetic Location
7q32.1
UCSC Genome Browser
View 7q32.1 on the UCSC genome browser
2.
Identifier
rs712700
Cytogenetic Location
7q32.1
UCSC Genome Browser
View 7q32.1 on the UCSC genome browser
3.
Identifier
rs327517
Cytogenetic Location
7q32.1
UCSC Genome Browser
View 7q32.1 on the UCSC genome browser

Gene details

HGNC symbol
PAX4
Aliases
KPD; MODY9 
Common name
paired box 4 
Description
This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box 4 gene is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
2
OMIM
167413
Ensembl
ENSG00000106331
UniProt/Swiss-Prot
PAX4_HUMAN
Entrez Gene
5078
UniGene
129706
HapMap
View on HapMap

Homologs in model organisms

Mus musculus
Pax4
Rattus norvegicus
Pax4

References

Park et al. (2009)

Other variants which are also part of this study