LongevityMap variant group

Entry Details

Longevity Association
Significant
Population
Chinese (Han)
Study Design
Three SNPs in FOXO1A and three in FOXO3A were analyzed in a sample of 760 centenarians (578 female and 182 male) and 1060 middle-age controls (378 female and 682 male)
Conclusions
In FOXO1A, rs2755209 and rs2755213 were found to be negatively associated with longevity in women (OR = 0.70 and 0.71, p = .007 and .015; dominant model). In the dominant model for men, FOXO1A-rs2755213 was marginally and negatively associated with longevity (OR = 0.65, p = .025) and the association of FOXO1A- rs2755209 is not significant (OR = 0.73, p = .093).

Variants (2)

1.
Identifier
rs2755209
In Other Studies (IDs)
473 586 1564 2253
Cytogenetic Location
13q14.11
UCSC Genome Browser
View 13q14.11 on the UCSC genome browser
2.
Identifier
rs2755213
In Other Studies (IDs)
476 593 1582
Cytogenetic Location
13q14.11
UCSC Genome Browser
View 13q14.11 on the UCSC genome browser

Gene details

HGNC symbol
FOXO1
Aliases
FKH1; FKHR; FOXO1A 
Common name
forkhead box O1 
Description
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
30
OMIM
136533
Ensembl
ENSG00000150907
UniProt/Swiss-Prot
FOXO1_HUMAN
Entrez Gene
2308
UniGene
370666
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
foxo1b
Mus musculus
Foxo1
Rattus norvegicus
Foxo1

In other databases

GenAge human genes
  • This gene is present as FOXO1

References

Zeng et al. (2010)

Other variants which are also part of this study