LongevityMap variant group

Entry Details

Longevity Association
Non-significant
Population
Germany, Italian, Chinese (Han)
Study Design
36 haplotype-tagging SNPs (htSNPs) in the gene regions of FOXO1, FOXO4, and FOXO6 were examined in Germany cohort which consist of 1447 centenarians/nonagenarians (95-110 y, mean age: 98.8 y, approx. 75% female) and 1029 younger controls (60-75 y, mean age: 66.8 y, approx. 75% female) for longevity association analysis. Then these htSNPs were examined in Italian women samples which consist of 166 long-lived individuals (90–109 years, mean age: 98.39 years) and 216 younger controls (18–48 years; mean age: 31.06 years).
Conclusions
None of the FOXO1, FOXO4, and FOXO6 genes plays a significant role in the ability to reach old age in Germany. FOXO1 was not associated with longevity in Italian either.

Variants (32)

No gene

1.
Identifier
rs2701893
Cytogenetic Location
2.
Identifier
rs2721047
Cytogenetic Location

FOXO1

1.
Identifier
rs17446593
Cytogenetic Location
13q14.11
UCSC Genome Browser
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2.
Identifier
rs2755209
In Other Studies (IDs)
473 586 1670 2253
Cytogenetic Location
13q14.11
UCSC Genome Browser
View 13q14.11 on the UCSC genome browser
3.
Identifier
rs1078892
Cytogenetic Location
13q14.11
UCSC Genome Browser
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4.
Identifier
rs2701859
Cytogenetic Location
13q14.11
UCSC Genome Browser
View 13q14.11 on the UCSC genome browser
5.
Identifier
rs12865518
Cytogenetic Location
13q14.11
UCSC Genome Browser
View 13q14.11 on the UCSC genome browser
6.
Identifier
rs2721069
In Other Studies (IDs)
589
Cytogenetic Location
13q14.11
UCSC Genome Browser
View 13q14.11 on the UCSC genome browser
7.
Identifier
rs2755213
In Other Studies (IDs)
476 593 1673
Cytogenetic Location
13q14.11
UCSC Genome Browser
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8.
Identifier
rs2701880
Cytogenetic Location
13q14.11
UCSC Genome Browser
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9.
Identifier
rs2951787
Cytogenetic Location
13q14.11
UCSC Genome Browser
View 13q14.11 on the UCSC genome browser
10.
Identifier
rs2984121
Cytogenetic Location
13q14.11
UCSC Genome Browser
View 13q14.11 on the UCSC genome browser
11.
Identifier
rs2721044
Cytogenetic Location
13q14.11
UCSC Genome Browser
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12.
Identifier
rs4943794
In Other Studies (IDs)
1418
Cytogenetic Location
13q14.11
UCSC Genome Browser
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13.
Identifier
rs1986649
Cytogenetic Location
13q14.11
UCSC Genome Browser
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14.
Identifier
rs17630266
Cytogenetic Location
13q14.11
UCSC Genome Browser
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15.
Identifier
rs12876443
Cytogenetic Location
13q14.11
UCSC Genome Browser
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16.
Identifier
rs7981045
Cytogenetic Location
13q14.11
UCSC Genome Browser
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17.
Identifier
rs9603776
Cytogenetic Location
13q14.11
UCSC Genome Browser
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Gene details

HGNC symbol
FOXO1
Aliases
FKH1; FKHR; FOXO1A 
Common name
forkhead box O1 
Description
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
30
OMIM
136533
Ensembl
ENSG00000150907
UniProt/Swiss-Prot
FOXO1_HUMAN
Entrez Gene
2308
UniGene
370666
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
foxo1b
Mus musculus
Foxo1
Rattus norvegicus
Foxo1

In other databases

GenAge human genes
  • This gene is present as FOXO1

FOXO4

1.
Identifier
rs12013673
In Other Studies (IDs)
2258
Cytogenetic Location
Xq13.1
UCSC Genome Browser
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2.
Identifier
rs5981072
Cytogenetic Location
Xq13.1
UCSC Genome Browser
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Gene details

HGNC symbol
FOXO4
Aliases
AFX; AFX1; MLLT7 
Common name
forkhead box O4 
Description
This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Other longevity studies of this gene
5
OMIM
300033
Ensembl
ENSG00000184481
UniProt/Swiss-Prot
FOXO4_HUMAN
Entrez Gene
4303
UniGene
584654
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
LOC563719
Drosophila melanogaster
foxo
Mus musculus
Foxo4
Rattus norvegicus
Foxo4
Saccharomyces cerevisiae
FHL1
Schizosaccharomyces pombe
sep1

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as foxo
GenAge human genes
  • This gene is present as FOXO4
GenDR gene manipulations
  • A homolog of this gene for Drosophila melanogaster is present as foxo

FOXO6

1.
Identifier
rs11585393
Cytogenetic Location
1p34.2
UCSC Genome Browser
View 1p34.2 on the UCSC genome browser
2.
Identifier
rs7539614
Cytogenetic Location
1p34.2
UCSC Genome Browser
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3.
Identifier
rs7547654
Cytogenetic Location
1p34.2
UCSC Genome Browser
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4.
Identifier
rs11581271
Cytogenetic Location
1p34.2
UCSC Genome Browser
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5.
Identifier
rs1317558
Cytogenetic Location
1p34.2
UCSC Genome Browser
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6.
Identifier
rs1317557
Cytogenetic Location
1p34.2
UCSC Genome Browser
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7.
Identifier
rs6693260
Cytogenetic Location
1p34.2
UCSC Genome Browser
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8.
Identifier
rs4660532
Cytogenetic Location
1p34.2
UCSC Genome Browser
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9.
Identifier
rs6690527
Cytogenetic Location
1p34.2
UCSC Genome Browser
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10.
Identifier
rs4660192
Cytogenetic Location
1p34.2
UCSC Genome Browser
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11.
Identifier
rs11209971
Cytogenetic Location
1p34.2
UCSC Genome Browser
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Gene details

HGNC symbol
FOXO6
Aliases
 
Common name
forkhead box O6 
Description
Other longevity studies of this gene
10
OMIM
611457
Ensembl
UniProt/Swiss-Prot
Entrez Gene
100132074
UniGene
559677
HapMap
View on HapMap

Homologs in model organisms

No homologs found

References

Kleindorp et al. (2011)

Other variants which are also part of this study