LongevityMap variant group

Entry Details

Longevity Association
Non-significant
Population
German
Study Design
Genotyping of 56 single nucleotide polymorphisms located in the CYP2C gene family was performed for 1384 unrelated long-lived individuals (age range: 95-109 years, mean: 98.8 years), including 616 centenarians (mean age: 101.3 years), and 945 younger controls (age range: 60-75 years, mean: 66.9 years). The gender ratio was 73% females versus 27% males.
Conclusions
None of the tested single nucleotide polymorphisms showed a significant association with the longevity phenotype at the allele, genotype, or haplotype level

Variants (56)

No gene

1.
Identifier
rs1934954
Cytogenetic Location

CYP2C18

1.
Identifier
rs10736086
Cytogenetic Location
10q23.33
UCSC Genome Browser
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2.
Identifier
rs12249418
Cytogenetic Location
10q23.33
UCSC Genome Browser
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3.
Identifier
rs1575934
Cytogenetic Location
10q23.33
UCSC Genome Browser
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4.
Identifier
rs7896133
Cytogenetic Location
10q23.33
UCSC Genome Browser
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5.
Identifier
rs11188059
Cytogenetic Location
10q23.33
UCSC Genome Browser
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6.
Identifier
rs7914753
Cytogenetic Location
10q23.33
UCSC Genome Browser
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7.
Identifier
rs2281891
Cytogenetic Location
10q23.33
UCSC Genome Browser
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8.
Identifier
rs1042192
Cytogenetic Location
10q23.33
UCSC Genome Browser
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9.
Identifier
rs1042194
Cytogenetic Location
10q23.33
UCSC Genome Browser
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10.
Identifier
rs1326830
Cytogenetic Location
10q23.33
UCSC Genome Browser
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Gene details

HGNC symbol
CYP2C18
Aliases
CPCI; CYP2C; CYP2C17; P450IIC17; P450-6B/29C 
Common name
cytochrome P450 family 2 subfamily C member 18 
Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
9
OMIM
601131
Ensembl
ENSG00000108242
UniProt/Swiss-Prot
CP2CI_HUMAN
Entrez Gene
1562
UniGene
511872
HapMap
View on HapMap

Homologs in model organisms

No homologs found

CYP2C19

1.
Identifier
rs12248560
Cytogenetic Location
10q23.33
UCSC Genome Browser
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2.
Identifier
rs4986894
Cytogenetic Location
10q23.33
UCSC Genome Browser
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3.
Identifier
rs6583954
Cytogenetic Location
10q23.33
UCSC Genome Browser
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4.
Identifier
rs4388808
Cytogenetic Location
10q23.33
UCSC Genome Browser
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5.
Identifier
rs7088784
Cytogenetic Location
10q23.33
UCSC Genome Browser
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6.
Identifier
rs1322179
Cytogenetic Location
10q23.33
UCSC Genome Browser
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7.
Identifier
rs10786172
Cytogenetic Location
10q23.33
UCSC Genome Browser
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8.
Identifier
rs12253253
Cytogenetic Location
10q23.33
UCSC Genome Browser
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9.
Identifier
rs7915414
Cytogenetic Location
10q23.33
UCSC Genome Browser
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10.
Identifier
rs1555474
Cytogenetic Location
10q23.33
UCSC Genome Browser
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11.
Identifier
rs4917623
Cytogenetic Location
10q23.33
UCSC Genome Browser
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Gene details

HGNC symbol
CYP2C19
Aliases
CPCJ; CYP2C; P450C2C; CYPIIC17; CYPIIC19; P450IIC19 
Common name
cytochrome P450 family 2 subfamily C member 19 
Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
10
OMIM
124020
Ensembl
ENSG00000165841
UniProt/Swiss-Prot
CP2CJ_HUMAN
Entrez Gene
1557
UniGene
282409
HapMap
View on HapMap

Homologs in model organisms

Mus musculus
Cyp2c38
Rattus norvegicus
Cyp2c24

CYP2C58P

1.
Identifier
rs11592225
Cytogenetic Location
10q23.33
UCSC Genome Browser
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Gene details

HGNC symbol
CYP2C58P
Aliases
 
Common name
cytochrome P450 family 2 subfamily C member 58, pseudogene 
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene
106480430
UniGene
HapMap
View on HapMap

Homologs in model organisms

No homologs found

CYP2C8

1.
Identifier
rs11572181
Cytogenetic Location
10q23.33
UCSC Genome Browser
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2.
Identifier
rs1058932
Cytogenetic Location
10q23.33
UCSC Genome Browser
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3.
Identifier
rs1934952
Cytogenetic Location
10q23.33
UCSC Genome Browser
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4.
Identifier
rs10509681
Cytogenetic Location
10q23.33
UCSC Genome Browser
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5.
Identifier
rs2275620
Cytogenetic Location
10q23.33
UCSC Genome Browser
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6.
Identifier
rs1891073
Cytogenetic Location
10q23.33
UCSC Genome Browser
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7.
Identifier
rs11572139
Cytogenetic Location
10q23.33
UCSC Genome Browser
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8.
Identifier
rs6583967
Cytogenetic Location
10q23.33
UCSC Genome Browser
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9.
Identifier
rs11572127
Cytogenetic Location
10q23.33
UCSC Genome Browser
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10.
Identifier
rs1058930
Cytogenetic Location
10q23.33
UCSC Genome Browser
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11.
Identifier
rs10882525
Cytogenetic Location
10q23.33
UCSC Genome Browser
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12.
Identifier
rs17110453
Cytogenetic Location
10q23.33
UCSC Genome Browser
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13.
Identifier
rs1557044
Cytogenetic Location
10q23.33
UCSC Genome Browser
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Gene details

HGNC symbol
CYP2C8
Aliases
CPC8; CYPIIC8; MP-12/MP-20 
Common name
cytochrome P450 family 2 subfamily C member 8 
Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Other longevity studies of this gene
12
OMIM
601129
Ensembl
ENSG00000138115
UniProt/Swiss-Prot
B7Z1F5_HUMAN
Entrez Gene
1558
UniGene
709188
HapMap
View on HapMap

Homologs in model organisms

No homologs found

CYP2C9

1.
Identifier
rs2475377
Cytogenetic Location
10q23.33
UCSC Genome Browser
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2.
Identifier
rs4918758
Cytogenetic Location
10q23.33
UCSC Genome Browser
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3.
Identifier
rs9332105
Cytogenetic Location
10q23.33
UCSC Genome Browser
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4.
Identifier
rs9332113
Cytogenetic Location
10q23.33
UCSC Genome Browser
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5.
Identifier
rs12772884
Cytogenetic Location
10q23.33
UCSC Genome Browser
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6.
Identifier
rs1799853
Cytogenetic Location
10q23.33
UCSC Genome Browser
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7.
Identifier
rs12572351
Cytogenetic Location
10q23.33
UCSC Genome Browser
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8.
Identifier
rs4918766
Cytogenetic Location
10q23.33
UCSC Genome Browser
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9.
Identifier
rs2475376
Cytogenetic Location
10q23.33
UCSC Genome Browser
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10.
Identifier
rs2153628
Cytogenetic Location
10q23.33
UCSC Genome Browser
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11.
Identifier
rs1856908
Cytogenetic Location
10q23.33
UCSC Genome Browser
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12.
Identifier
rs9332197
Cytogenetic Location
10q23.33
UCSC Genome Browser
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13.
Identifier
rs1057910
Cytogenetic Location
10q23.33
UCSC Genome Browser
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14.
Identifier
rs1934967
Cytogenetic Location
10q23.33
UCSC Genome Browser
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15.
Identifier
rs2153629
Cytogenetic Location
10q23.33
UCSC Genome Browser
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16.
Identifier
rs9332222
Cytogenetic Location
10q23.33
UCSC Genome Browser
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17.
Identifier
rs1057911
Cytogenetic Location
10q23.33
UCSC Genome Browser
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18.
Identifier
rs9332242
Cytogenetic Location
10q23.33
UCSC Genome Browser
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19.
Identifier
rs9332245
Cytogenetic Location
10q23.33
UCSC Genome Browser
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20.
Identifier
rs4918797
Cytogenetic Location
10q23.33
UCSC Genome Browser
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Gene details

HGNC symbol
CYP2C9
Aliases
CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9 
Common name
cytochrome P450 family 2 subfamily C member 9 
Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
19
OMIM
601130
Ensembl
ENSG00000138109
UniProt/Swiss-Prot
CP2C9_HUMAN
Entrez Gene
1559
UniGene
282624
HapMap
View on HapMap

Homologs in model organisms

No homologs found

References

Flachsbart et al. (2011)

Other variants which are also part of this study