LongevityMap variant group

Entry Details

Longevity Association
Non-significant
Population
American of Japanese origin
Study Design
85 multiethnic (Caucasian, Filipino, Japanese, Chinese, and mixed ethnicity; aged 10- 78 y) sequences were chosen to determine allele frequency. Then 282 Americans of Japanese ancestry were examined for the allele frequency. Furthermore, 675 Hawaii Lifespan Study case (>95 y, average 97.9 y)-control(< 81 y, average 78.5 y) study participants were examined for the allele frequency.
Conclusions
All 38 of the previously reported coding SNPs in FOXO3 are either invalid or too rare to be useful for phenotype–genotype association and other genetic mapping studies. These are likely not involved in longevity. A novel identified SNP (rs138174682) is prevalent in multiple ethnic groups but too rare for longevity analysis in Hawaii Lifespan Study.

Variants (39)

1.
Identifier
rs111556510
Cytogenetic Location
6q21
UCSC Genome Browser
View 6q21 on the UCSC genome browser
2.
Identifier
rs112124249
Cytogenetic Location
6q21
UCSC Genome Browser
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3.
Identifier
rs11551770
Cytogenetic Location
6q21
UCSC Genome Browser
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4.
Identifier
rs11757217
Cytogenetic Location
6q21
UCSC Genome Browser
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5.
Identifier
rs13204476
Cytogenetic Location
6q21
UCSC Genome Browser
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6.
Identifier
rs138174682
Cytogenetic Location
6q21
UCSC Genome Browser
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7.
Identifier
rs138297794
Cytogenetic Location
6q21
UCSC Genome Browser
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8.
Identifier
rs138742093
Cytogenetic Location
6q21
UCSC Genome Browser
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9.
Identifier
rs139172563
Cytogenetic Location
6q21
UCSC Genome Browser
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10.
Identifier
rs140968061
Cytogenetic Location
6q21
UCSC Genome Browser
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11.
Identifier
rs141876866
Cytogenetic Location
6q21
UCSC Genome Browser
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12.
Identifier
rs141893794
Cytogenetic Location
6q21
UCSC Genome Browser
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13.
Identifier
rs142429317
Cytogenetic Location
6q21
UCSC Genome Browser
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14.
Identifier
rs142533192
Cytogenetic Location
6q21
UCSC Genome Browser
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15.
Identifier
rs145259784
Cytogenetic Location
6q21
UCSC Genome Browser
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16.
Identifier
rs145756480
Cytogenetic Location
6q21
UCSC Genome Browser
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17.
Identifier
rs146009555
Cytogenetic Location
6q21
UCSC Genome Browser
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18.
Identifier
rs146169955
Cytogenetic Location
6q21
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19.
Identifier
rs146186567
Cytogenetic Location
6q21
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20.
Identifier
rs147010831
Cytogenetic Location
6q21
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21.
Identifier
rs147028825
Cytogenetic Location
6q21
UCSC Genome Browser
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22.
Identifier
rs148296241
Cytogenetic Location
6q21
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23.
Identifier
rs148405845
Cytogenetic Location
6q21
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24.
Identifier
rs149158541
Cytogenetic Location
6q21
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25.
Identifier
rs149189425
Cytogenetic Location
6q21
UCSC Genome Browser
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26.
Identifier
rs149503832
Cytogenetic Location
6q21
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27.
Identifier
rs149906214
Cytogenetic Location
6q21
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28.
Identifier
rs150216371
Cytogenetic Location
6q21
UCSC Genome Browser
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29.
Identifier
rs150320900
Cytogenetic Location
6q21
UCSC Genome Browser
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30.
Identifier
rs150535671
Cytogenetic Location
6q21
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31.
Identifier
rs34079373
Cytogenetic Location
6q21
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32.
Identifier
rs34133353
Cytogenetic Location
6q21
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33.
Identifier
rs34223850
Cytogenetic Location
6q21
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34.
Identifier
rs34488332
Cytogenetic Location
6q21
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35.
Identifier
rs34600091
Cytogenetic Location
6q21
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36.
Identifier
rs34754045
Cytogenetic Location
6q21
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37.
Identifier
rs61756661
Cytogenetic Location
6q21
UCSC Genome Browser
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38.
Identifier
rs61758963
Cytogenetic Location
6q21
UCSC Genome Browser
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39.
Identifier
rs79884776
Cytogenetic Location
6q21
UCSC Genome Browser
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Gene details

HGNC symbol
FOXO3
Aliases
FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2 
Common name
forkhead box O3 
Description
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
101
OMIM
602681
Ensembl
ENSG00000118689
UniProt/Swiss-Prot
FOXO3_HUMAN
Entrez Gene
2309
UniGene
220950
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
foxo3a
Mus musculus
Foxo3
Rattus norvegicus
Foxo3

In other databases

GenAge human genes
  • This gene is present as FOXO3
GenDR gene manipulations
  • A homolog of this gene for Mus musculus is present as Foxo3
CellAge
  • This gene is present as FOXO3

References

Donlon et al. (2012)

Other variants which are also part of this study