LongevityMap variant group

Entry Details

Longevity Association
Non-significant
Population
American of Japanese origin
Study Design
Nested-case control study of 5 candidate longevity genes in 8006 Japanese American men from the Honolulu Heart Program and 3741 men part of the Honolulu Asia Aging Study
Conclusions
Genetic variants in ADIPOQ, FOXO1A, SIRT1 and COQ7 were not associated with longevity

Variants (12)

ADIPOQ

1.
Identifier
rs1063539
Cytogenetic Location
3q27.3
UCSC Genome Browser
View 3q27.3 on the UCSC genome browser
2.
Identifier
rs182052
Cytogenetic Location
3q27.3
UCSC Genome Browser
View 3q27.3 on the UCSC genome browser
3.
Identifier
rs266729
In Other Studies (IDs)
2866
Cytogenetic Location
3q27.3
UCSC Genome Browser
View 3q27.3 on the UCSC genome browser

Gene details

HGNC symbol
ADIPOQ
Aliases
ACDC; ADPN; APM1; APM-1; GBP28; ACRP30; ADIPQTL1 
Common name
adiponectin, C1Q and collagen domain containing 
Description
This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]
Other longevity studies of this gene
8
OMIM
605441
Ensembl
ENSG00000181092
UniProt/Swiss-Prot
A8K660_HUMAN
Entrez Gene
9370
UniGene
80485
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
col-75
Danio rerio
adipoqb
Mus musculus
Adipoq
Rattus norvegicus
Adipoq

COQ7

1.
Identifier
rs8051232
Cytogenetic Location
16p12.3
UCSC Genome Browser
View 16p12.3 on the UCSC genome browser
2.
Identifier
rs11074359
Cytogenetic Location
16p12.3
UCSC Genome Browser
View 16p12.3 on the UCSC genome browser
3.
Identifier
rs7192898
Cytogenetic Location
16p12.3
UCSC Genome Browser
View 16p12.3 on the UCSC genome browser

Gene details

HGNC symbol
COQ7
Aliases
CAT5; CLK1; CLK-1; COQ10D8 
Common name
coenzyme Q7, hydroxylase 
Description
The protein encoded by this gene is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces cerevisiae that is involved with ubiquinone biosynthesis. Mutations in the yeast gene lead to slower development and longer life span. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]
Other longevity studies of this gene
2
OMIM
601683
Ensembl
ENSG00000167186
UniProt/Swiss-Prot
COQ7_HUMAN
Entrez Gene
10229
UniGene
157113
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
clk-1
Danio rerio
zgc:158731
Drosophila melanogaster
COQ7
Mus musculus
Coq7
Rattus norvegicus
Coq7
Saccharomyces cerevisiae
CAT5
Schizosaccharomyces pombe
coq7

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as clk-1
  • A homolog of this gene for Mus musculus is present as Coq7
  • A homolog of this gene for Saccharomyces cerevisiae is present as CAT5
GenAge human genes
  • This gene is present as COQ7
GenDR gene manipulations
  • A homolog of this gene for Caenorhabditis elegans is present as clk-1

FOXO1

1.
Identifier
rs2755209
In Other Studies (IDs)
473 1564 1670 2253
Cytogenetic Location
13q14.11
UCSC Genome Browser
View 13q14.11 on the UCSC genome browser
2.
Identifier
rs2721069
In Other Studies (IDs)
1579
Cytogenetic Location
13q14.11
UCSC Genome Browser
View 13q14.11 on the UCSC genome browser
3.
Identifier
rs2755213
In Other Studies (IDs)
476 1582 1673
Cytogenetic Location
13q14.11
UCSC Genome Browser
View 13q14.11 on the UCSC genome browser

Gene details

HGNC symbol
FOXO1
Aliases
FKH1; FKHR; FOXO1A 
Common name
forkhead box O1 
Description
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
30
OMIM
136533
Ensembl
ENSG00000150907
UniProt/Swiss-Prot
FOXO1_HUMAN
Entrez Gene
2308
UniGene
370666
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
foxo1b
Mus musculus
Foxo1
Rattus norvegicus
Foxo1

In other databases

GenAge human genes
  • This gene is present as FOXO1

SIRT1

1.
Identifier
rs7069102
In Other Studies (IDs)
2120
Cytogenetic Location
10q21.3
UCSC Genome Browser
View 10q21.3 on the UCSC genome browser
2.
Identifier
rs10823112
Cytogenetic Location
10q21.3
UCSC Genome Browser
View 10q21.3 on the UCSC genome browser
3.
Identifier
rs1885472
Cytogenetic Location
10q21.3
UCSC Genome Browser
View 10q21.3 on the UCSC genome browser

Gene details

HGNC symbol
SIRT1
Aliases
SIR2; SIR2L1; SIR2alpha 
Common name
sirtuin 1 
Description
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Other longevity studies of this gene
33
OMIM
604479
Ensembl
ENSG00000096717
UniProt/Swiss-Prot
A0A024QZQ1_HUMAN
Entrez Gene
23411
UniGene
369779
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
sir-2.1
Danio rerio
sirt1
Drosophila melanogaster
Sir2
Mus musculus
Sirt1
Rattus norvegicus
Sirt1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as sir-2.1
  • A homolog of this gene for Drosophila melanogaster is present as Sir2
  • A homolog of this gene for Mus musculus is present as Sirt1
GenAge human genes
  • This gene is present as SIRT1
GenDR gene manipulations
  • A homolog of this gene for Drosophila melanogaster is present as Sir2
  • A homolog of this gene for Mus musculus is present as Sirt1
  • A homolog of this gene for Caenorhabditis elegans is present as sir-2.1
CellAge
  • This gene is present as SIRT1

References

Willcox et al. (2008)

Other variants which are also part of this study