LongevityMap variant group

Entry Details

Longevity Association
Non-significant
Population
Caucasians
Study Design
Meta-analysis of GWAS in Caucasians from four prospective cohort studies: the Age, Gene/Environment Susceptibility-Reykjavik Study, the Cardiovascular Health Study, the Framingham Heart Study, and the Rotterdam Study participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Longevity was defined as survival to age 90 years or older (n = 1,836); the comparison group comprised cohort members who died between the ages of 55 and 80 years (n = 1,955).
Conclusions
There were 273 single-nucleotide polymorphism (SNP) associations with p < .0001, but none reached significance after correcting for multiple testing

Variants (287)

No gene

1.
Identifier
rs2495702
Cytogenetic Location
2.
Identifier
rs3124736
Cytogenetic Location
3.
Identifier
rs17606668
Cytogenetic Location
4.
Identifier
rs2583125
Cytogenetic Location
5.
Identifier
rs2583124
Cytogenetic Location
6.
Identifier
rs10502177
Cytogenetic Location
7.
Identifier
rs17612378
Cytogenetic Location
8.
Identifier
rs11607718
Cytogenetic Location
9.
Identifier
rs11604887
Cytogenetic Location
10.
Identifier
rs11611975
Cytogenetic Location
11.
Identifier
rs10843049
Cytogenetic Location
12.
Identifier
rs11049255
Cytogenetic Location
13.
Identifier
rs11049256
Cytogenetic Location
14.
Identifier
rs42294
Cytogenetic Location
15.
Identifier
rs33083
Cytogenetic Location
16.
Identifier
rs886347
Cytogenetic Location
17.
Identifier
rs1333420
Cytogenetic Location
18.
Identifier
rs7324138
Cytogenetic Location
19.
Identifier
rs12854616
Cytogenetic Location
20.
Identifier
rs12875277
Cytogenetic Location
21.
Identifier
rs17073844
Cytogenetic Location
22.
Identifier
rs7321904
Cytogenetic Location
23.
Identifier
rs1333416
Cytogenetic Location
24.
Identifier
rs17073955
Cytogenetic Location
25.
Identifier
rs7155742
Cytogenetic Location
26.
Identifier
rs1543505
Cytogenetic Location
27.
Identifier
rs4982702
Cytogenetic Location
28.
Identifier
rs4982703
Cytogenetic Location
29.
Identifier
rs8012963
Cytogenetic Location
30.
Identifier
rs4982705
Cytogenetic Location
31.
Identifier
rs234577
Cytogenetic Location
32.
Identifier
rs766410
Cytogenetic Location
33.
Identifier
rs4494555
Cytogenetic Location
34.
Identifier
rs1955389
Cytogenetic Location
35.
Identifier
rs1955390
Cytogenetic Location
36.
Identifier
rs2344495
Cytogenetic Location
37.
Identifier
rs11642341
Cytogenetic Location
38.
Identifier
rs11642677
Cytogenetic Location
39.
Identifier
rs1033867
Cytogenetic Location
40.
Identifier
rs16850255
Cytogenetic Location
41.
Identifier
rs12094387
Cytogenetic Location
42.
Identifier
rs1534957
Cytogenetic Location
43.
Identifier
rs7531849
Cytogenetic Location
44.
Identifier
rs6035189
Cytogenetic Location
45.
Identifier
rs1535487
Cytogenetic Location
46.
Identifier
rs7584841
Cytogenetic Location
47.
Identifier
rs10179640
Cytogenetic Location
48.
Identifier
rs6710634
Cytogenetic Location
49.
Identifier
rs4485702
Cytogenetic Location
50.
Identifier
rs4367043
Cytogenetic Location
51.
Identifier
rs10510303
Cytogenetic Location
52.
Identifier
rs7624691
Cytogenetic Location
53.
Identifier
rs11710086
Cytogenetic Location
54.
Identifier
rs11710916
Cytogenetic Location
55.
Identifier
rs1811483
Cytogenetic Location
56.
Identifier
rs4287919
Cytogenetic Location
57.
Identifier
rs9883089
Cytogenetic Location
58.
Identifier
rs9831924
Cytogenetic Location
59.
Identifier
rs4856642
Cytogenetic Location
60.
Identifier
rs9831040
Cytogenetic Location
61.
Identifier
rs2221517
Cytogenetic Location
62.
Identifier
rs2221516
Cytogenetic Location
63.
Identifier
rs7621711
Cytogenetic Location
64.
Identifier
rs6781716
Cytogenetic Location
65.
Identifier
rs9868834
Cytogenetic Location
66.
Identifier
rs6793693
Cytogenetic Location
67.
Identifier
rs7620901
Cytogenetic Location
68.
Identifier
rs6441391
Cytogenetic Location
69.
Identifier
rs2048801
Cytogenetic Location
70.
Identifier
rs1588907
Cytogenetic Location
71.
Identifier
rs9290087
Cytogenetic Location
72.
Identifier
rs1399904
Cytogenetic Location
73.
Identifier
rs9813121
Cytogenetic Location
74.
Identifier
rs1399910
Cytogenetic Location
75.
Identifier
rs1878064
Cytogenetic Location
76.
Identifier
rs1399906
Cytogenetic Location
77.
Identifier
rs9871565
Cytogenetic Location
78.
Identifier
rs9876608
Cytogenetic Location
79.
Identifier
rs9876363
Cytogenetic Location
80.
Identifier
rs9877938
Cytogenetic Location
81.
Identifier
rs1515741
Cytogenetic Location
82.
Identifier
rs1850000
Cytogenetic Location
83.
Identifier
rs1399916
Cytogenetic Location
84.
Identifier
rs1515743
Cytogenetic Location
85.
Identifier
rs1568020
Cytogenetic Location
86.
Identifier
rs4305435
Cytogenetic Location
87.
Identifier
rs2203490
Cytogenetic Location
88.
Identifier
rs1515724
Cytogenetic Location
89.
Identifier
rs1399915
Cytogenetic Location
90.
Identifier
rs12501388
Cytogenetic Location
91.
Identifier
rs12499249
Cytogenetic Location
92.
Identifier
rs4279252
Cytogenetic Location
93.
Identifier
rs2035912
Cytogenetic Location
94.
Identifier
rs4691183
Cytogenetic Location
95.
Identifier
rs7667236
Cytogenetic Location
96.
Identifier
rs2333491
Cytogenetic Location
97.
Identifier
rs1872500
Cytogenetic Location
98.
Identifier
rs6850916
Cytogenetic Location
99.
Identifier
rs2739532
Cytogenetic Location
100.
Identifier
rs10036031
Cytogenetic Location
101.
Identifier
rs12202794
Cytogenetic Location
102.
Identifier
rs954551
Cytogenetic Location
103.
Identifier
rs9377361
Cytogenetic Location
104.
Identifier
rs9377363
Cytogenetic Location
105.
Identifier
rs7771560
Cytogenetic Location
106.
Identifier
rs9285551
Cytogenetic Location
107.
Identifier
rs1416280
Cytogenetic Location
108.
Identifier
rs10252600
Cytogenetic Location
109.
Identifier
rs6472566
Cytogenetic Location
110.
Identifier
rs10957534
Cytogenetic Location
111.
Identifier
rs13277069
Cytogenetic Location
112.
Identifier
rs6990397
Cytogenetic Location
113.
Identifier
rs10957743
Cytogenetic Location
114.
Identifier
rs2956605
Cytogenetic Location
115.
Identifier
rs11778674
Cytogenetic Location
116.
Identifier
rs17369174
Cytogenetic Location
117.
Identifier
rs17369209
Cytogenetic Location
118.
Identifier
rs11785349
Cytogenetic Location
119.
Identifier
rs17297422
Cytogenetic Location
120.
Identifier
rs7813189
Cytogenetic Location
121.
Identifier
rs4348534
Cytogenetic Location
122.
Identifier
rs10990103
Cytogenetic Location
123.
Identifier
rs10760894
Cytogenetic Location

ASIC2

1.
Identifier
rs12952455
Cytogenetic Location
17q11.2-q12
UCSC Genome Browser
View 17q11.2-q12 on the UCSC genome browser
2.
Identifier
rs9972933
Cytogenetic Location
17q11.2-q12
UCSC Genome Browser
View 17q11.2-q12 on the UCSC genome browser
3.
Identifier
rs9972931
Cytogenetic Location
17q11.2-q12
UCSC Genome Browser
View 17q11.2-q12 on the UCSC genome browser

Gene details

HGNC symbol
ASIC2
Aliases
ACCN; BNC1; MDEG; ACCN1; BNaC1; ASIC2a; hBNaC1 
Common name
acid sensing ion channel subunit 2 
Description
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]
Other longevity studies of this gene
3
OMIM
601784
Ensembl
ENSG00000108684
UniProt/Swiss-Prot
ASIC2_HUMAN
Entrez Gene
40
UniGene
368417
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
asic2
Mus musculus
Asic2
Rattus norvegicus
Asic2

CALB2

1.
Identifier
rs12444419
Cytogenetic Location
16q22.2
UCSC Genome Browser
View 16q22.2 on the UCSC genome browser
2.
Identifier
rs8046337
Cytogenetic Location
16q22.2
UCSC Genome Browser
View 16q22.2 on the UCSC genome browser
3.
Identifier
rs11641122
Cytogenetic Location
16q22.2
UCSC Genome Browser
View 16q22.2 on the UCSC genome browser

Gene details

HGNC symbol
CALB2
Aliases
CR; CAL2; CAB29 
Common name
calbindin 2 
Description
This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Other longevity studies of this gene
2
OMIM
114051
Ensembl
ENSG00000172137
UniProt/Swiss-Prot
A0A140VK08_HUMAN
Entrez Gene
794
UniGene
106857
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
calb2a
Mus musculus
Calb2
Rattus norvegicus
Calb2

CERS3

1.
Identifier
rs12914235
Cytogenetic Location
15q26.3
UCSC Genome Browser
View 15q26.3 on the UCSC genome browser
2.
Identifier
rs1023782
Cytogenetic Location
15q26.3
UCSC Genome Browser
View 15q26.3 on the UCSC genome browser
3.
Identifier
rs7180354
Cytogenetic Location
15q26.3
UCSC Genome Browser
View 15q26.3 on the UCSC genome browser
4.
Identifier
rs1000290
Cytogenetic Location
15q26.3
UCSC Genome Browser
View 15q26.3 on the UCSC genome browser
5.
Identifier
rs7164184
Cytogenetic Location
15q26.3
UCSC Genome Browser
View 15q26.3 on the UCSC genome browser
6.
Identifier
rs1393943
Cytogenetic Location
15q26.3
UCSC Genome Browser
View 15q26.3 on the UCSC genome browser
7.
Identifier
rs2654602
Cytogenetic Location
15q26.3
UCSC Genome Browser
View 15q26.3 on the UCSC genome browser
8.
Identifier
rs2587803
Cytogenetic Location
15q26.3
UCSC Genome Browser
View 15q26.3 on the UCSC genome browser
9.
Identifier
rs1988459
Cytogenetic Location
15q26.3
UCSC Genome Browser
View 15q26.3 on the UCSC genome browser
10.
Identifier
rs8028050
Cytogenetic Location
15q26.3
UCSC Genome Browser
View 15q26.3 on the UCSC genome browser
11.
Identifier
rs8029244
Cytogenetic Location
15q26.3
UCSC Genome Browser
View 15q26.3 on the UCSC genome browser
12.
Identifier
rs8028803
Cytogenetic Location
15q26.3
UCSC Genome Browser
View 15q26.3 on the UCSC genome browser
13.
Identifier
rs12910887
Cytogenetic Location
15q26.3
UCSC Genome Browser
View 15q26.3 on the UCSC genome browser
14.
Identifier
rs12906592
Cytogenetic Location
15q26.3
UCSC Genome Browser
View 15q26.3 on the UCSC genome browser
15.
Identifier
rs1466931
Cytogenetic Location
15q26.3
UCSC Genome Browser
View 15q26.3 on the UCSC genome browser
16.
Identifier
rs1466930
Cytogenetic Location
15q26.3
UCSC Genome Browser
View 15q26.3 on the UCSC genome browser
17.
Identifier
rs11634135
Cytogenetic Location
15q26.3
UCSC Genome Browser
View 15q26.3 on the UCSC genome browser
18.
Identifier
rs1393942
Cytogenetic Location
15q26.3
UCSC Genome Browser
View 15q26.3 on the UCSC genome browser

Gene details

HGNC symbol
CERS3
Aliases
ARCI9; LASS3 
Common name
ceramide synthase 3 
Description
This gene is a member of the ceramide synthase family of genes. The ceramide synthase enzymes regulate sphingolipid synthesis by catalyzing the formation of ceramides from sphingoid base and acyl-coA substrates. This family member is involved in the synthesis of ceramides with ultra-long-chain acyl moieties (ULC-Cers), important to the epidermis in its role in creating a protective barrier from the environment. The protein encoded by this gene has also been implicated in modification of the lipid structures required for spermatogenesis. Mutations in this gene have been associated with male fertility defects, and epidermal defects, including ichthyosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
Other longevity studies of this gene
17
OMIM
615276
Ensembl
ENSG00000154227
UniProt/Swiss-Prot
CERS3_HUMAN
Entrez Gene
204219
UniGene
662371
HapMap
View on HapMap

Homologs in model organisms

Mus musculus
Cers3
Rattus norvegicus
Cers3

CERS3-AS1

1.
Identifier
rs2587748
Cytogenetic Location
15q26.3
UCSC Genome Browser
View 15q26.3 on the UCSC genome browser
2.
Identifier
rs2587736
Cytogenetic Location
15q26.3
UCSC Genome Browser
View 15q26.3 on the UCSC genome browser

Gene details

HGNC symbol
CERS3-AS1
Aliases
 
Common name
CERS3 antisense RNA 1 
Description
Other longevity studies of this gene
1
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene
102723320
UniGene
416099
HapMap
View on HapMap

Homologs in model organisms

No homologs found

CHIAP2

1.
Identifier
rs12027550
Cytogenetic Location
1p13.2
UCSC Genome Browser
View 1p13.2 on the UCSC genome browser

Gene details

HGNC symbol
CHIAP2
Aliases
 
Common name
chitinase, acidic pseudogene 2 
Description
OMIM
Ensembl
ENSG00000203878
UniProt/Swiss-Prot
Entrez Gene
149620
UniGene
736960
HapMap
View on HapMap

Homologs in model organisms

No homologs found

CHST4

1.
Identifier
rs4149497
Cytogenetic Location
16q22.2
UCSC Genome Browser
View 16q22.2 on the UCSC genome browser

Gene details

HGNC symbol
CHST4
Aliases
GST3; LSST; GlcNAc6ST2; HECGLCNAC6ST 
Common name
carbohydrate sulfotransferase 4 
Description
This gene encodes an N-acetylglucosamine 6-O sulfotransferase. The encoded enzyme transfers sulfate from 3'phosphoadenosine 5'phospho-sulfate to the 6-hydroxyl group of N-acetylglucosamine on glycoproteins. This protein is localized to the Golgi and is involved in the modification of glycan structures on ligands of the lymphocyte homing receptor L-selectin. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]
OMIM
Ensembl
ENSG00000140835
UniProt/Swiss-Prot
CHST4_HUMAN
Entrez Gene
10164
UniGene
251383
HapMap
View on HapMap

Homologs in model organisms

Mus musculus
Chst4
Rattus norvegicus
Chst4

CLEC3A

1.
Identifier
rs2293776
Cytogenetic Location
16q23.1
UCSC Genome Browser
View 16q23.1 on the UCSC genome browser

Gene details

HGNC symbol
CLEC3A
Aliases
CLECSF1 
Common name
C-type lectin domain family 3 member A 
Description
OMIM
613588
Ensembl
ENSG00000166509
UniProt/Swiss-Prot
CLC3A_HUMAN
Entrez Gene
10143
UniGene
177936
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
clec-44
Danio rerio
LOC100330122
Mus musculus
Clec3a
Rattus norvegicus
Clec3a

DIRAS2

1.
Identifier
rs690232
Cytogenetic Location
9q22.2
UCSC Genome Browser
View 9q22.2 on the UCSC genome browser

Gene details

HGNC symbol
DIRAS2
Aliases
Di-Ras2 
Common name
DIRAS family GTPase 2 
Description
DIRAS2 belongs to a distinct branch of the functionally diverse Ras (see HRAS; MIM 190020) superfamily of monomeric GTPases.[supplied by OMIM, Apr 2004]
OMIM
607863
Ensembl
ENSG00000165023
UniProt/Swiss-Prot
DIRA2_HUMAN
Entrez Gene
54769
UniGene
165636
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
LOC560940
Mus musculus
Diras2
Rattus norvegicus
Diras2

DRD2

1.
Identifier
rs12364051
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser

Gene details

HGNC symbol
DRD2
Aliases
D2R; D2DR 
Common name
dopamine receptor D2 
Description
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
2
OMIM
126450
Ensembl
ENSG00000149295
UniProt/Swiss-Prot
A0A024R3C5_HUMAN
Entrez Gene
1813
UniGene
73893
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
drd2a
Drosophila melanogaster
D2R
Mus musculus
Drd2
Rattus norvegicus
Drd2

FASTKD3

1.
Identifier
rs16879258
Cytogenetic Location
5p15.31
UCSC Genome Browser
View 5p15.31 on the UCSC genome browser

Gene details

HGNC symbol
FASTKD3
Aliases
 
Common name
FAST kinase domains 3 
Description
This gene encodes a member of a small family of Fas-activated serine/threonine kinase domain (FASTKD) containing proteins that share an amino terminal mitochondrial targeting domain and multiple carboxy terminal FAST domains as well as a putative RNA-binding RAP domain. The members of this family are ubiquitously expressed and are generally most abundant in mitochondria-enriched tissues such as heart, skeletal muscle and brown-adipose tissue. Some members of this protein family may play a role in apoptosis. The protein encoded by this gene interacts with components of the mitochondrial respiratory and translation networks. A pseudogene of this gene is also present on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
OMIM
Ensembl
ENSG00000124279
UniProt/Swiss-Prot
FAKD3_HUMAN
Entrez Gene
79072
UniGene
653162
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
fastkd3
Mus musculus
Fastkd3
Rattus norvegicus
Fastkd3

GNA14

1.
Identifier
rs13288161
Cytogenetic Location
9q21.2
UCSC Genome Browser
View 9q21.2 on the UCSC genome browser

Gene details

HGNC symbol
GNA14
Aliases
 
Common name
G protein subunit alpha 14 
Description
This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant activation of phospholipase C-beta and its downstream effectors.[provided by RefSeq, Feb 2009]
OMIM
604397
Ensembl
ENSG00000156049
UniProt/Swiss-Prot
GNA14_HUMAN
Entrez Gene
9630
UniGene
657795
HapMap
View on HapMap

Homologs in model organisms

Drosophila melanogaster
Galpha49B
Mus musculus
Gna14
Rattus norvegicus
Gna14
Saccharomyces cerevisiae
GPA1

HOXD3

1.
Identifier
rs1348807
Cytogenetic Location
2q31.1
UCSC Genome Browser
View 2q31.1 on the UCSC genome browser

Gene details

HGNC symbol
HOXD3
Aliases
HOX4; HOX1D; HOX4A; Hox-4.1 
Common name
homeobox D3 
Description
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes. [provided by RefSeq, Jul 2008]
OMIM
142980
Ensembl
ENSG00000128652
UniProt/Swiss-Prot
HXD3_HUMAN
Entrez Gene
3232
UniGene
93574
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
hoxd3a
Drosophila melanogaster
pb
Mus musculus
Hoxd3

KIAA0368

1.
Identifier
rs2274899
Cytogenetic Location
9q31.3
UCSC Genome Browser
View 9q31.3 on the UCSC genome browser

Gene details

HGNC symbol
KIAA0368
Aliases
ECM29 
Common name
KIAA0368 
Description
OMIM
616694
Ensembl
ENSG00000136813
UniProt/Swiss-Prot
ECM29_HUMAN
Entrez Gene
23392
UniGene
368255
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
CELE_D2045.2
Danio rerio
LOC563777
Drosophila melanogaster
CG8858
Mus musculus
Ecm29
Rattus norvegicus
AI314180
Saccharomyces cerevisiae
ECM29
Schizosaccharomyces pombe
ecm29

LAPTM5

1.
Identifier
rs3795437
Cytogenetic Location
1p35.2
UCSC Genome Browser
View 1p35.2 on the UCSC genome browser
2.
Identifier
rs12404920
Cytogenetic Location
1p35.2
UCSC Genome Browser
View 1p35.2 on the UCSC genome browser

Gene details

HGNC symbol
LAPTM5
Aliases
CLAST6 
Common name
lysosomal protein transmembrane 5 
Description
This gene encodes a transmembrane receptor that is associated with lysosomes. The encoded protein, also known as E3 protein, may play a role in hematopoiesis. [provided by RefSeq, Feb 2009]
Other longevity studies of this gene
1
OMIM
601476
Ensembl
ENSG00000162511
UniProt/Swiss-Prot
LAPM5_HUMAN
Entrez Gene
7805
UniGene
371021
HapMap
View on HapMap

Homologs in model organisms

Mus musculus
Laptm5
Rattus norvegicus
Laptm5

In other databases

GenAge microarray genes
  • This gene is present as LAPTM5

LINC01446

1.
Identifier
rs13235506
Cytogenetic Location
7p12.1
UCSC Genome Browser
View 7p12.1 on the UCSC genome browser

Gene details

HGNC symbol
LINC01446
Aliases
GS1-179L18.1 
Common name
long intergenic non-protein coding RNA 1446 
Description
OMIM
Ensembl
ENSG00000205628
UniProt/Swiss-Prot
Entrez Gene
401337
UniGene
531378
HapMap
View on HapMap

Homologs in model organisms

No homologs found

LINC01599

1.
Identifier
rs11625406
Cytogenetic Location
14q21.3
UCSC Genome Browser
View 14q21.3 on the UCSC genome browser
2.
Identifier
rs11157721
Cytogenetic Location
14q21.3
UCSC Genome Browser
View 14q21.3 on the UCSC genome browser
3.
Identifier
rs9323180
Cytogenetic Location
14q21.3
UCSC Genome Browser
View 14q21.3 on the UCSC genome browser
4.
Identifier
rs1950705
Cytogenetic Location
14q21.3
UCSC Genome Browser
View 14q21.3 on the UCSC genome browser
5.
Identifier
rs941604
Cytogenetic Location
14q21.3
UCSC Genome Browser
View 14q21.3 on the UCSC genome browser

Gene details

HGNC symbol
LINC01599
Aliases
C14orf183 
Common name
long intergenic non-protein coding RNA 1599 
Description
Other longevity studies of this gene
4
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene
196913
UniGene
406934
HapMap
View on HapMap

Homologs in model organisms

No homologs found

LINC01901

1.
Identifier
rs12967168
Cytogenetic Location
18q12.3
UCSC Genome Browser
View 18q12.3 on the UCSC genome browser
2.
Identifier
rs11082159
Cytogenetic Location
18q12.3
UCSC Genome Browser
View 18q12.3 on the UCSC genome browser

Gene details

HGNC symbol
LINC01901
Aliases
 
Common name
long intergenic non-protein coding RNA 1901 
Description
Other longevity studies of this gene
1
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene
105372080
UniGene
HapMap
View on HapMap

Homologs in model organisms

No homologs found

LINC01902

1.
Identifier
rs16972414
Cytogenetic Location
18q12.3
UCSC Genome Browser
View 18q12.3 on the UCSC genome browser

Gene details

HGNC symbol
LINC01902
Aliases
 
Common name
long intergenic non-protein coding RNA 1902 
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene
105372079
UniGene
HapMap
View on HapMap

Homologs in model organisms

No homologs found

LINC02331

1.
Identifier
rs210332
Cytogenetic Location
14q22.2
UCSC Genome Browser
View 14q22.2 on the UCSC genome browser

Gene details

HGNC symbol
LINC02331
Aliases
 
Common name
long intergenic non-protein coding RNA 2331 
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene
105370503
UniGene
HapMap
View on HapMap

Homologs in model organisms

No homologs found

LOC100506929

1.
Identifier
rs4443878
Cytogenetic Location
1q43
UCSC Genome Browser
View 1q43 on the UCSC genome browser
2.
Identifier
rs4611001
Cytogenetic Location
1q43
UCSC Genome Browser
View 1q43 on the UCSC genome browser

Gene details

HGNC symbol
LOC100506929
Aliases
 
Common name
uncharacterized LOC100506929 
Description
Other longevity studies of this gene
1
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene
100506929
UniGene
HapMap
View on HapMap

Homologs in model organisms

No homologs found

LOC102724929

1.
Identifier
rs10114818
Cytogenetic Location
9q33.1
UCSC Genome Browser
View 9q33.1 on the UCSC genome browser

Gene details

HGNC symbol
LOC102724929
Aliases
 
Common name
uncharacterized LOC102724929 
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene
102724929
UniGene
HapMap
View on HapMap

Homologs in model organisms

No homologs found

LOC105374430

1.
Identifier
rs17593986
Cytogenetic Location
4p13
UCSC Genome Browser
View 4p13 on the UCSC genome browser

Gene details

HGNC symbol
LOC105374430
Aliases
 
Common name
uncharacterized LOC105374430 
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene
105374430
UniGene
HapMap
View on HapMap

Homologs in model organisms

No homologs found

LOC105375670

1.
Identifier
rs4734457
Cytogenetic Location
8q22.2-q22.3
UCSC Genome Browser
View 8q22.2-q22.3 on the UCSC genome browser

Gene details

HGNC symbol
LOC105375670
Aliases
 
Common name
uncharacterized LOC105375670 
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene
105375670
UniGene
HapMap
View on HapMap

Homologs in model organisms

No homologs found

LOC105376360

1.
Identifier
rs10508257
Cytogenetic Location
10p15.2
UCSC Genome Browser
View 10p15.2 on the UCSC genome browser

Gene details

HGNC symbol
LOC105376360
Aliases
 
Common name
uncharacterized LOC105376360 
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene
105376360
UniGene
212226
HapMap
View on HapMap

Homologs in model organisms

No homologs found

LOC105376823

1.
Identifier
rs6686814
Cytogenetic Location
1p36.13
UCSC Genome Browser
View 1p36.13 on the UCSC genome browser
2.
Identifier
rs16823061
Cytogenetic Location
1p36.13
UCSC Genome Browser
View 1p36.13 on the UCSC genome browser
3.
Identifier
rs7517912
Cytogenetic Location
1p36.13
UCSC Genome Browser
View 1p36.13 on the UCSC genome browser
4.
Identifier
rs12064952
Cytogenetic Location
1p36.13
UCSC Genome Browser
View 1p36.13 on the UCSC genome browser

Gene details

HGNC symbol
LOC105376823
Aliases
 
Common name
uncharacterized LOC105376823 
Description
Other longevity studies of this gene
3
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene
105376823
UniGene
HapMap
View on HapMap

Homologs in model organisms

No homologs found

LOC105377356

1.
Identifier
rs17293880
Cytogenetic Location
4q24-q25
UCSC Genome Browser
View 4q24-q25 on the UCSC genome browser

Gene details

HGNC symbol
LOC105377356
Aliases
 
Common name
uncharacterized LOC105377356 
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene
105377356
UniGene
HapMap
View on HapMap

Homologs in model organisms

No homologs found

LOC105377519

1.
Identifier
rs7655392
Cytogenetic Location
4q32.3
UCSC Genome Browser
View 4q32.3 on the UCSC genome browser
2.
Identifier
rs4690810
Cytogenetic Location
4q32.3
UCSC Genome Browser
View 4q32.3 on the UCSC genome browser

Gene details

HGNC symbol
LOC105377519
Aliases
 
Common name
uncharacterized LOC105377519 
Description
Other longevity studies of this gene
1
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene
105377519
UniGene
HapMap
View on HapMap

Homologs in model organisms

No homologs found

LOC107984390

1.
Identifier
rs11607834
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
2.
Identifier
rs11607852
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
3.
Identifier
rs3923972
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
4.
Identifier
rs17603387
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
5.
Identifier
rs11601692
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
6.
Identifier
rs11605737
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
7.
Identifier
rs17531898
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
8.
Identifier
rs11601402
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
9.
Identifier
rs17610557
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
10.
Identifier
rs17532157
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
11.
Identifier
rs17532254
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
12.
Identifier
rs11602504
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
13.
Identifier
rs17532375
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
14.
Identifier
rs17610915
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
15.
Identifier
rs17532479
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
16.
Identifier
rs11600717
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
17.
Identifier
rs11602934
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
18.
Identifier
rs11601890
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
19.
Identifier
rs11607594
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
20.
Identifier
rs11607622
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
21.
Identifier
rs11607747
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
22.
Identifier
rs11602134
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
23.
Identifier
rs11606746
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
24.
Identifier
rs1355202
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
25.
Identifier
rs11605078
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
26.
Identifier
rs11605096
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
27.
Identifier
rs11600908
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
28.
Identifier
rs11606211
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
29.
Identifier
rs11606336
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
30.
Identifier
rs11607704
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
31.
Identifier
rs17611093
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
32.
Identifier
rs17611127
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
33.
Identifier
rs11604194
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
34.
Identifier
rs17532884
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser

Gene details

HGNC symbol
LOC107984390
Aliases
 
Common name
uncharacterized LOC107984390 
Description
Other longevity studies of this gene
33
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene
107984390
UniGene
HapMap
View on HapMap

Homologs in model organisms

No homologs found

LOC107984897

1.
Identifier
rs2344922
Cytogenetic Location
16q23.1
UCSC Genome Browser
View 16q23.1 on the UCSC genome browser
2.
Identifier
rs8045479
Cytogenetic Location
16q23.1
UCSC Genome Browser
View 16q23.1 on the UCSC genome browser
3.
Identifier
rs8044195
Cytogenetic Location
16q23.1
UCSC Genome Browser
View 16q23.1 on the UCSC genome browser
4.
Identifier
rs4369682
Cytogenetic Location
16q23.1
UCSC Genome Browser
View 16q23.1 on the UCSC genome browser
5.
Identifier
rs11150040
Cytogenetic Location
16q23.1
UCSC Genome Browser
View 16q23.1 on the UCSC genome browser

Gene details

HGNC symbol
LOC107984897
Aliases
 
Common name
uncharacterized LOC107984897 
Description
Other longevity studies of this gene
4
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene
107984897
UniGene
HapMap
View on HapMap

Homologs in model organisms

No homologs found

LOC107986150

1.
Identifier
rs16832246
Cytogenetic Location
3q26.1
UCSC Genome Browser
View 3q26.1 on the UCSC genome browser
2.
Identifier
rs11713185
Cytogenetic Location
3q26.1
UCSC Genome Browser
View 3q26.1 on the UCSC genome browser
3.
Identifier
rs16832279
Cytogenetic Location
3q26.1
UCSC Genome Browser
View 3q26.1 on the UCSC genome browser

Gene details

HGNC symbol
LOC107986150
Aliases
 
Common name
uncharacterized LOC107986150 
Description
Other longevity studies of this gene
2
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene
107986150
UniGene
HapMap
View on HapMap

Homologs in model organisms

No homologs found

LOC107987056

1.
Identifier
rs12003047
Cytogenetic Location
9p21.3
UCSC Genome Browser
View 9p21.3 on the UCSC genome browser

Gene details

HGNC symbol
LOC107987056
Aliases
 
Common name
uncharacterized LOC107987056 
Description
OMIM
Ensembl
UniProt/Swiss-Prot
Entrez Gene
107987056
UniGene
HapMap
View on HapMap

Homologs in model organisms

No homologs found

LOC643542

1.
Identifier
rs12956332
Cytogenetic Location
18q22.1
UCSC Genome Browser
View 18q22.1 on the UCSC genome browser
2.
Identifier
rs12958645
Cytogenetic Location
18q22.1
UCSC Genome Browser
View 18q22.1 on the UCSC genome browser
3.
Identifier
rs12963356
Cytogenetic Location
18q22.1
UCSC Genome Browser
View 18q22.1 on the UCSC genome browser
4.
Identifier
rs7237695
Cytogenetic Location
18q22.1
UCSC Genome Browser
View 18q22.1 on the UCSC genome browser
5.
Identifier
rs12605030
Cytogenetic Location
18q22.1
UCSC Genome Browser
View 18q22.1 on the UCSC genome browser
6.
Identifier
rs12965352
Cytogenetic Location
18q22.1
UCSC Genome Browser
View 18q22.1 on the UCSC genome browser
7.
Identifier
rs2440514
Cytogenetic Location
18q22.1
UCSC Genome Browser
View 18q22.1 on the UCSC genome browser

Gene details

HGNC symbol
LOC643542
Aliases
 
Common name
uncharacterized LOC643542 
Description
Other longevity studies of this gene
6
OMIM
Ensembl
ENSG00000265533
UniProt/Swiss-Prot
Entrez Gene
643542
UniGene
652901
HapMap
View on HapMap

Homologs in model organisms

No homologs found

LYPD6

1.
Identifier
rs1420356
Cytogenetic Location
2q23.2
UCSC Genome Browser
View 2q23.2 on the UCSC genome browser

Gene details

HGNC symbol
LYPD6
Aliases
 
Common name
LY6/PLAUR domain containing 6 
Description
Members of the LY6 protein family (see SLURP1; MIM 606119), such as LYPD6, have at least one 80-amino acid LU domain that contains 10 conserved cysteines with a defined disulfide-bonding pattern (Zhang et al., 2010 [PubMed 19653121]).[supplied by OMIM, Apr 2010]
OMIM
613359
Ensembl
ENSG00000187123
UniProt/Swiss-Prot
LYPD6_HUMAN
Entrez Gene
130574
UniGene
21929
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
lypd6
Mus musculus
Lypd6
Rattus norvegicus
Lypd6

MACROD2

1.
Identifier
rs2423969
Cytogenetic Location
20p12.1
UCSC Genome Browser
View 20p12.1 on the UCSC genome browser
2.
Identifier
rs2423970
Cytogenetic Location
20p12.1
UCSC Genome Browser
View 20p12.1 on the UCSC genome browser
3.
Identifier
rs1362512
Cytogenetic Location
20p12.1
UCSC Genome Browser
View 20p12.1 on the UCSC genome browser

Gene details

HGNC symbol
MACROD2
Aliases
C2orf133; C20orf133 
Common name
MACRO domain containing 2 
Description
Other longevity studies of this gene
2
OMIM
611567
Ensembl
ENSG00000172264
UniProt/Swiss-Prot
MACD2_HUMAN
Entrez Gene
140733
UniGene
661576
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
B0035.3
Mus musculus
Macrod2

MAN2B2

1.
Identifier
rs7654633
Cytogenetic Location
4p16.1
UCSC Genome Browser
View 4p16.1 on the UCSC genome browser

Gene details

HGNC symbol
MAN2B2
Aliases
 
Common name
mannosidase alpha class 2B member 2 
Description
OMIM
Ensembl
ENSG00000013288
UniProt/Swiss-Prot
B7Z754_HUMAN
Entrez Gene
23324
UniGene
188464
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
man2b2
Mus musculus
Man2b2
Rattus norvegicus
Man2b2

MSC-AS1

1.
Identifier
rs17799174
Cytogenetic Location
8q13.3-q21.11
UCSC Genome Browser
View 8q13.3-q21.11 on the UCSC genome browser

Gene details

HGNC symbol
MSC-AS1
Aliases
 
Common name
MSC antisense RNA 1 
Description
OMIM
Ensembl
ENSG00000235531
UniProt/Swiss-Prot
Entrez Gene
100132891
UniGene
137674
HapMap
View on HapMap

Homologs in model organisms

No homologs found

MSMO1

1.
Identifier
rs1866218
Cytogenetic Location
4q32.3
UCSC Genome Browser
View 4q32.3 on the UCSC genome browser
2.
Identifier
rs2322292
Cytogenetic Location
4q32.3
UCSC Genome Browser
View 4q32.3 on the UCSC genome browser

Gene details

HGNC symbol
MSMO1
Aliases
DESP4; ERG25; MCCPD; SC4MOL 
Common name
methylsterol monooxygenase 1 
Description
Sterol-C4-mehtyl oxidase-like protein was isolated based on its similarity to the yeast ERG25 protein. It contains a set of putative metal binding motifs with similarity to that seen in a family of membrane desaturases-hydroxylases. The protein is localized to the endoplasmic reticulum membrane and is believed to function in cholesterol biosynthesis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
1
OMIM
607545
Ensembl
ENSG00000052802
UniProt/Swiss-Prot
MSMO1_HUMAN
Entrez Gene
6307
UniGene
105269
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
msmo1
Mus musculus
Msmo1
Rattus norvegicus
Msmo1
Saccharomyces cerevisiae
ERG25
Schizosaccharomyces pombe
erg25

MTA3

1.
Identifier
rs17029781
Cytogenetic Location
2p21
UCSC Genome Browser
View 2p21 on the UCSC genome browser
2.
Identifier
rs17679678
Cytogenetic Location
2p21
UCSC Genome Browser
View 2p21 on the UCSC genome browser

Gene details

HGNC symbol
MTA3
Aliases
 
Common name
metastasis associated 1 family member 3 
Description
Other longevity studies of this gene
1
OMIM
609050
Ensembl
ENSG00000057935
UniProt/Swiss-Prot
D6W5A2_HUMAN
Entrez Gene
57504
UniGene
435413
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
mta3
Mus musculus
Mta3
Rattus norvegicus
Mta3

MYO18B

1.
Identifier
rs6004864
Cytogenetic Location
22q12.1
UCSC Genome Browser
View 22q12.1 on the UCSC genome browser
2.
Identifier
rs6004867
Cytogenetic Location
22q12.1
UCSC Genome Browser
View 22q12.1 on the UCSC genome browser
3.
Identifier
rs16981163
Cytogenetic Location
22q12.1
UCSC Genome Browser
View 22q12.1 on the UCSC genome browser
4.
Identifier
rs8136667
Cytogenetic Location
22q12.1
UCSC Genome Browser
View 22q12.1 on the UCSC genome browser
5.
Identifier
rs9620582
Cytogenetic Location
22q12.1
UCSC Genome Browser
View 22q12.1 on the UCSC genome browser
6.
Identifier
rs6004887
Cytogenetic Location
22q12.1
UCSC Genome Browser
View 22q12.1 on the UCSC genome browser
7.
Identifier
rs6004890
Cytogenetic Location
22q12.1
UCSC Genome Browser
View 22q12.1 on the UCSC genome browser

Gene details

HGNC symbol
MYO18B
Aliases
KFS4 
Common name
myosin XVIIIB 
Description
The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
6
OMIM
607295
Ensembl
ENSG00000133454
UniProt/Swiss-Prot
A0A075B6F5_HUMAN
Entrez Gene
84700
UniGene
417959
HapMap
View on HapMap

Homologs in model organisms

Mus musculus
Myo18b
Rattus norvegicus
Myo18b

NEO1

1.
Identifier
rs7170328
Cytogenetic Location
15q24.1
UCSC Genome Browser
View 15q24.1 on the UCSC genome browser
2.
Identifier
rs16957640
Cytogenetic Location
15q24.1
UCSC Genome Browser
View 15q24.1 on the UCSC genome browser
3.
Identifier
rs7177629
Cytogenetic Location
15q24.1
UCSC Genome Browser
View 15q24.1 on the UCSC genome browser
4.
Identifier
rs6495056
Cytogenetic Location
15q24.1
UCSC Genome Browser
View 15q24.1 on the UCSC genome browser
5.
Identifier
rs7163504
Cytogenetic Location
15q24.1
UCSC Genome Browser
View 15q24.1 on the UCSC genome browser

Gene details

HGNC symbol
NEO1
Aliases
NGN; IGDCC2; NTN1R2 
Common name
neogenin 1 
Description
This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Other longevity studies of this gene
4
OMIM
601907
Ensembl
ENSG00000067141
UniProt/Swiss-Prot
NEO1_HUMAN
Entrez Gene
4756
UniGene
388613
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
unc-40
Danio rerio
neo1
Drosophila melanogaster
fra
Mus musculus
Neo1
Rattus norvegicus
Neo1

OR2W3

1.
Identifier
rs10888267
Cytogenetic Location
1q44
UCSC Genome Browser
View 1q44 on the UCSC genome browser

Gene details

HGNC symbol
OR2W3
Aliases
OR2W3P; OR2W8P; OST718 
Common name
olfactory receptor family 2 subfamily W member 3 
Description
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OMIM
616729
Ensembl
ENSG00000238243
UniProt/Swiss-Prot
OR2W3_HUMAN
Entrez Gene
343171
UniGene
269151
HapMap
View on HapMap

Homologs in model organisms

Mus musculus
Olfr317
Rattus norvegicus
Olr1433

OR6Y1

1.
Identifier
rs9804152
Cytogenetic Location
1q23.1
UCSC Genome Browser
View 1q23.1 on the UCSC genome browser

Gene details

HGNC symbol
OR6Y1
Aliases
OR6Y2; OR1-11 
Common name
olfactory receptor family 6 subfamily Y member 1 
Description
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OMIM
Ensembl
ENSG00000197532
UniProt/Swiss-Prot
OR6Y1_HUMAN
Entrez Gene
391112
UniGene
553780
HapMap
View on HapMap

Homologs in model organisms

Mus musculus
Olfr220
Rattus norvegicus
Olr1602

OTUD3

1.
Identifier
rs4654910
Cytogenetic Location
1p36.13
UCSC Genome Browser
View 1p36.13 on the UCSC genome browser
2.
Identifier
rs17401847
Cytogenetic Location
1p36.13
UCSC Genome Browser
View 1p36.13 on the UCSC genome browser

Gene details

HGNC symbol
OTUD3
Aliases
DUBA4 
Common name
OTU deubiquitinase 3 
Description
Other longevity studies of this gene
1
OMIM
611758
Ensembl
ENSG00000169914
UniProt/Swiss-Prot
OTUD3_HUMAN
Entrez Gene
23252
UniGene
374987
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
otud3
Mus musculus
Otud3
Rattus norvegicus
Otud3

PABPC4

1.
Identifier
rs11577939
Cytogenetic Location
1p34.3
UCSC Genome Browser
View 1p34.3 on the UCSC genome browser

Gene details

HGNC symbol
PABPC4
Aliases
APP1; APP-1; PABP4; iPABP 
Common name
poly(A) binding protein cytoplasmic 4 
Description
Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
OMIM
603407
Ensembl
ENSG00000090621
UniProt/Swiss-Prot
PABP4_HUMAN
Entrez Gene
8761
UniGene
169900
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
pabpc4
Mus musculus
Pabpc4
Rattus norvegicus
Pabpc4

PARP1

1.
Identifier
rs3219142
In Other Studies (IDs)
3061
Cytogenetic Location
1q42.12
UCSC Genome Browser
View 1q42.12 on the UCSC genome browser

Gene details

HGNC symbol
PARP1
Aliases
PARP; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT; 1; pADPRT-1 
Common name
poly(ADP-ribose) polymerase 1 
Description
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
15
OMIM
173870
Ensembl
ENSG00000143799
UniProt/Swiss-Prot
A0A024R3T8_HUMAN
Entrez Gene
142
UniGene
177766
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
pme-1
Danio rerio
parp1
Drosophila melanogaster
Parp
Mus musculus
Parp1
Rattus norvegicus
Parp1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as pme-1
GenAge human genes
  • This gene is present as PARP1

PPARGC1A

1.
Identifier
rs2970848
Cytogenetic Location
4p15.2
UCSC Genome Browser
View 4p15.2 on the UCSC genome browser

Gene details

HGNC symbol
PPARGC1A
Aliases
LEM6; PGC1; PGC1A; PGC-1v; PPARGC1; PGC-1alpha; PGC-1(alpha) 
Common name
PPARG coactivator 1 alpha 
Description
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
7
OMIM
604517
Ensembl
ENSG00000109819
UniProt/Swiss-Prot
A0A024R9Q9_HUMAN
Entrez Gene
10891
UniGene
527078
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
ppargc1a
Mus musculus
Ppargc1a
Rattus norvegicus
Ppargc1a

In other databases

GenAge human genes

PTPRN2

1.
Identifier
rs12698138
Cytogenetic Location
7q36.3
UCSC Genome Browser
View 7q36.3 on the UCSC genome browser

Gene details

HGNC symbol
PTPRN2
Aliases
IAR; ICAAR; PTPRP; IA-2beta; R-PTP-N2 
Common name
protein tyrosine phosphatase, receptor type N2 
Description
This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
OMIM
601698
Ensembl
ENSG00000155093
UniProt/Swiss-Prot
E7EM83_HUMAN
Entrez Gene
5799
UniGene
490789
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
ida-1
Danio rerio
ptprn2
Mus musculus
Ptprn2
Rattus norvegicus
Ptprn2

REM2

1.
Identifier
rs12891954
Cytogenetic Location
14q11.2
UCSC Genome Browser
View 14q11.2 on the UCSC genome browser

Gene details

HGNC symbol
REM2
Aliases
 
Common name
RRAD and GEM like GTPase 2 
Description
OMIM
616955
Ensembl
ENSG00000139890
UniProt/Swiss-Prot
REM2_HUMAN
Entrez Gene
161253
UniGene
444911
HapMap
View on HapMap

Homologs in model organisms

Mus musculus
Rem2
Rattus norvegicus
Rem2

RNASEH1

1.
Identifier
rs4595985
Cytogenetic Location
2p25.3
UCSC Genome Browser
View 2p25.3 on the UCSC genome browser
2.
Identifier
rs10153531
Cytogenetic Location
2p25.3
UCSC Genome Browser
View 2p25.3 on the UCSC genome browser

Gene details

HGNC symbol
RNASEH1
Aliases
RNH1; H1RNA; PEOB2 
Common name
ribonuclease H1 
Description
This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and is necessary for DNA replication and repair. This enzyme is present in both mitochondria and nuclei, which are resulted from translation of a single mRNA with two in-frame initiation start codons. The use of the first start codon produces the mitochondrial isoform and the use of the second start codon produces the nuclear isoform. The production of the mitochondrial isoform is modulated by an upstream open reading frame (uORF) which overlaps the first initiation start codon in human. An alternately spliced transcript variant has been found which encodes a shorter isoform. This gene has three pseudogenes; two of them are at different locations of chromosome 17 and one of them is on chromosome 1q32.2. [provided by RefSeq, Sep 2014]
Other longevity studies of this gene
1
OMIM
604123
Ensembl
ENSG00000171865
UniProt/Swiss-Prot
B3KUD4_HUMAN
Entrez Gene
246243
UniGene
568006
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
rnh-1.0
Danio rerio
rnaseh1
Drosophila melanogaster
rnh1
Mus musculus
Rnaseh1
Rattus norvegicus
Rnaseh1
Schizosaccharomyces pombe
rnh1

RORB

1.
Identifier
rs4745348
Cytogenetic Location
9q21.13
UCSC Genome Browser
View 9q21.13 on the UCSC genome browser

Gene details

HGNC symbol
RORB
Aliases
RZRB; NR1F2; ROR-BETA; RZR-BETA; bA133M9.1 
Common name
RAR related orphan receptor B 
Description
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014]
OMIM
601972
Ensembl
ENSG00000198963
UniProt/Swiss-Prot
Q58EY0_HUMAN
Entrez Gene
6096
UniGene
494178
HapMap
View on HapMap

Homologs in model organisms

No homologs found

RPS6KA2

1.
Identifier
rs12198299
Cytogenetic Location
6q27
UCSC Genome Browser
View 6q27 on the UCSC genome browser

Gene details

HGNC symbol
RPS6KA2
Aliases
RSK; HU-2; RSK3; p90RSK2; p90-RSK3; pp90RSK3; MAPKAPK1C; S6K-alpha; S6K-alpha2 
Common name
ribosomal protein S6 kinase A2 
Description
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternative splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2016]
OMIM
601685
Ensembl
ENSG00000071242
UniProt/Swiss-Prot
B7Z3B5_HUMAN
Entrez Gene
6196
UniGene
655277
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
rps6ka2
Mus musculus
Rps6ka2
Rattus norvegicus
Rps6ka2

SCN9A

1.
Identifier
rs6432908
Cytogenetic Location
2q24.3
UCSC Genome Browser
View 2q24.3 on the UCSC genome browser
2.
Identifier
rs1540874
Cytogenetic Location
2q24.3
UCSC Genome Browser
View 2q24.3 on the UCSC genome browser
3.
Identifier
rs7590179
Cytogenetic Location
2q24.3
UCSC Genome Browser
View 2q24.3 on the UCSC genome browser
4.
Identifier
rs6721003
Cytogenetic Location
2q24.3
UCSC Genome Browser
View 2q24.3 on the UCSC genome browser
5.
Identifier
rs4384809
Cytogenetic Location
2q24.3
UCSC Genome Browser
View 2q24.3 on the UCSC genome browser

Gene details

HGNC symbol
SCN9A
Aliases
PN1; ETHA; NENA; SFNP; FEB3B; NE-NA; GEFSP7; HSAN2D; Nav1.7 
Common name
sodium voltage-gated channel alpha subunit 9 
Description
This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. [provided by RefSeq, Aug 2009]
Other longevity studies of this gene
4
OMIM
603415
Ensembl
ENSG00000169432
UniProt/Swiss-Prot
SCN9A_HUMAN
Entrez Gene
6335
UniGene
439145
HapMap
View on HapMap

Homologs in model organisms

Mus musculus
Scn9a
Rattus norvegicus
Scn9a

SH3PXD2B

1.
Identifier
rs2569208
Cytogenetic Location
5q35.1
UCSC Genome Browser
View 5q35.1 on the UCSC genome browser
2.
Identifier
rs2247647
Cytogenetic Location
5q35.1
UCSC Genome Browser
View 5q35.1 on the UCSC genome browser

Gene details

HGNC symbol
SH3PXD2B
Aliases
FTHS; HOFI; TKS4; TSK4; FAD49; KIAA1295 
Common name
SH3 and PX domains 2B 
Description
This gene encodes an adapter protein that is characterized by a PX domain and four Src homology 3 domains. The encoded protein is required for podosome formation and is involved in cell adhesion and migration of numerous cell types. Mutations in this gene are the cause of Frank-ter Haar syndrome (FTHS), and also Borrone Dermato-Cardio-Skeletal (BDCS) syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Other longevity studies of this gene
1
OMIM
613293
Ensembl
ENSG00000174705
UniProt/Swiss-Prot
G3V144_HUMAN
Entrez Gene
285590
UniGene
285666
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
sh3pxd2b
Mus musculus
Sh3pxd2b
Rattus norvegicus
RGD1309926

SSBP3

1.
Identifier
rs11206344
Cytogenetic Location
1p32.3
UCSC Genome Browser
View 1p32.3 on the UCSC genome browser
2.
Identifier
rs6690450
Cytogenetic Location
1p32.3
UCSC Genome Browser
View 1p32.3 on the UCSC genome browser
3.
Identifier
rs213490
Cytogenetic Location
1p32.3
UCSC Genome Browser
View 1p32.3 on the UCSC genome browser

Gene details

HGNC symbol
SSBP3
Aliases
CSDP; SSDP; SSDP1 
Common name
single stranded DNA binding protein 3 
Description
Other longevity studies of this gene
2
OMIM
607390
Ensembl
ENSG00000157216
UniProt/Swiss-Prot
Q9NW25_HUMAN
Entrez Gene
23648
UniGene
476706
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
ssbp4
Mus musculus
Ssbp3
Rattus norvegicus
Ssbp3

TMPRSS5

1.
Identifier
rs11607690
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
2.
Identifier
rs11600570
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
3.
Identifier
rs11601425
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser

Gene details

HGNC symbol
TMPRSS5
Aliases
SPINESIN 
Common name
transmembrane protease, serine 5 
Description
This gene encodes a protein that belongs to the serine protease family. Serine proteases are known to be involved in many physiological and pathological processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Other longevity studies of this gene
2
OMIM
606751
Ensembl
ENSG00000166682
UniProt/Swiss-Prot
B7Z247_HUMAN
Entrez Gene
80975
UniGene
46720
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
uncharacterized_F1QP
Drosophila melanogaster
CG4914
Mus musculus
Tmprss5
Rattus norvegicus
Tmprss5

XXYLT1

1.
Identifier
rs2131879
Cytogenetic Location
3q29
UCSC Genome Browser
View 3q29 on the UCSC genome browser
2.
Identifier
rs2410845
Cytogenetic Location
3q29
UCSC Genome Browser
View 3q29 on the UCSC genome browser
3.
Identifier
rs9825185
Cytogenetic Location
3q29
UCSC Genome Browser
View 3q29 on the UCSC genome browser

Gene details

HGNC symbol
XXYLT1
Aliases
C3orf21 
Common name
xyloside xylosyltransferase 1 
Description
Other longevity studies of this gene
2
OMIM
614552
Ensembl
ENSG00000173950
UniProt/Swiss-Prot
A0A140T9D0_HUMAN
Entrez Gene
152002
UniGene
478741
HapMap
View on HapMap

Homologs in model organisms

Danio rerio
LOC100334669
Drosophila melanogaster
CG11388-RA
Mus musculus
Xxylt1
Rattus norvegicus
Xxylt1

ZNF19

1.
Identifier
rs12935091
Cytogenetic Location
16q22.2
UCSC Genome Browser
View 16q22.2 on the UCSC genome browser

Gene details

HGNC symbol
ZNF19
Aliases
KOX12 
Common name
zinc finger protein 19 
Description
The protein encoded by this gene contains a zinc finger, a nucleic acid-binding domain present in many transcription factors. This gene is located in a region next to ZNF23, a gene also encoding a zinc finger protein, on chromosome 16. [provided by RefSeq, Jul 2008]
OMIM
194525
Ensembl
ENSG00000157429
UniProt/Swiss-Prot
ZNF19_HUMAN
Entrez Gene
7567
UniGene
660076
HapMap
View on HapMap

Homologs in model organisms

No homologs found

ZW10

1.
Identifier
rs17541000
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser
2.
Identifier
rs17541153
Cytogenetic Location
11q23.2
UCSC Genome Browser
View 11q23.2 on the UCSC genome browser

Gene details

HGNC symbol
ZW10
Aliases
HZW10; KNTC1AP 
Common name
zw10 kinetochore protein 
Description
This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011]
Other longevity studies of this gene
1
OMIM
603954
Ensembl
ENSG00000086827
UniProt/Swiss-Prot
ZW10_HUMAN
Entrez Gene
9183
UniGene
503886
HapMap
View on HapMap

Homologs in model organisms

Caenorhabditis elegans
czw-1
Danio rerio
zw10
Drosophila melanogaster
mit(1)15
Mus musculus
Zw10
Rattus norvegicus
Zw10

References

Newman et al. (2010)

Other variants which are also part of this study