LongevityMap variant

Entry Details

Longevity Association
Significant
Population
Turkish
Study Design
354 individuals (18 - 95 years, mean age 55.35 ± 19.16 y; 175 females (20–95 years, mean age 55.44 ± 19.15 years) and 179 males (18–92 years, mean age 55.27 ± 19.22 years) were classified into four age groups as 20–40, 41–60, 61–80, >80. Then, IL-6 and MT2A polymorphisms were genotyped for longevity association study.
Conclusions
A highly statistically significant association was detected for IL-6 genotype and allele frequencies in aging (p < 0.001). No significant difference was found between the two genders (p > 0.05). IL-6 −174 C+ carriers are more advantageous for longevity.
Identifier
rs1800795
In Other Studies (IDs)
327 2108 2623
Cytogenetic Location
7p15.3
UCSC Genome Browser
View 7p15.3 on the UCSC genome browser

Gene details

HGNC symbol
IL6
Aliases
CDF; HGF; HSF; BSF2; IL-6; BSF-2; IFNB2; IFN-beta-2 
Common name
interleukin 6 
Description
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Other longevity studies of this gene
19
OMIM
147620
Ensembl
ENSG00000136244
UniProt/Swiss-Prot
B4DNQ5_HUMAN
Entrez Gene
3569
UniGene
654458
HapMap
View on HapMap

Homologs in model organisms

Mus musculus
Il6
Rattus norvegicus
Il6

In other databases

GenAge human genes
  • This gene is present as IL6

References

Kayaaltı et al. (2011)

Other variants which are also part of this study